Long-term impact of prenatal exposure to chemotherapy on executive functioning: an ERP study
| Autor: | Patrick Dupont, Sabine Deprez, Lieven Lagae, Kristel Van Calsteren, Ivan Myatchin, Tineke Vandenbroucke, Frédéric Amant, Rob Zink, Charlotte Sleurs, Jeroen Blommaert |
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| Přispěvatelé: | Amsterdam Reproduction & Development (AR&D), CCA - Cancer Treatment and Quality of Life, Obstetrics and Gynaecology |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Age and sex 050105 experimental psychology 03 medical and health sciences Executive Function 0302 clinical medicine Pregnancy Physiology (medical) Medicine Over treatment Humans 0501 psychology and cognitive sciences Child Prenatal exposure Evoked Potentials Response inhibition Chemotherapy business.industry 05 social sciences Cancer medicine.disease Sensory Systems 3. Good health Clinical Practice Neurology Prenatal Exposure Delayed Effects Female Neurology (clinical) business Pregnancy Complications Neoplastic 030217 neurology & neurosurgery |
| Zdroj: | Clinical neurophysiology, 130(9), 1655-1664. Elsevier Ireland Ltd Clinical Neurophysiology |
| ISSN: | 1655-1664 1388-2457 |
| Popis: | OBJECTIVE This study examines the long-term impact of prenatal exposure to chemotherapy on executive functioning and the contribution of late-prematurity to this effect, using event- related potentials. METHODS Mothers of the prenatal-exposed children (n=20) were diagnosed with cancer and received chemotherapeutic treatment during pregnancy. We recruited healthy controls (n=20) who were matched on a 1:1 ratio regarding prematurity, age and sex. We assessed executive functioning at the age of nine, using two event-related potential paradigms: a Go/Nogo paradigm to investigate processes of response inhibition and conflict monitoring, as well as a Posner paradigm to investigate spatial attention. RESULTS Lower potentials were found in prenatal-exposed children compared to controls in the Go/Nogo P3 and Posner positive slow wave. Moreover, prenatal-exposed children responded slower on the Posner paradigm compared to controls (p |
| Databáze: | OpenAIRE |
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