Neonatal acute liver failure due to enteroviruses: a 14 years single NICU experience
| Autor: | Gabriele Buttinelli, Olivier Danhaive, Andrea Dotta, Fiammetta Piersigilli, Iliana Bersani, Cinzia Auriti, Alessandra Di Pede, Francesca Diomedi-Camassei |
|---|---|
| Přispěvatelé: | UCL - SSS/IREC/PEDI - Pôle de Pédiatrie, UCL - (SLuc) Service de néonatologie, UCL - SSS/IREC/SLUC - Pôle St.-Luc |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Pediatrics medicine.medical_specialty Neonatal intensive care unit viruses 030106 microbiology Hepatosplenomegaly Neonatal hepatitis medicine.disease_cause 03 medical and health sciences Neonate Intensive Care Units Neonatal Enterovirus Infections medicine Humans Viral hepatitis Child Enterovirus medicine.diagnostic_test business.industry Mortality rate digestive oral and skin physiology Infant Newborn Liver failure Infant virus diseases Obstetrics and Gynecology Liver Failure Acute medicine.disease 030104 developmental biology Liver biopsy Pediatrics Perinatology and Child Health medicine.symptom Liver function tests business Infant Premature |
| Zdroj: | The journal of maternal-fetal & neonatal medicine, Vol. 33, no. 15, p. 2576-2580 (2020) |
| Popis: | BACKGROUND: Neonatal acute liver failure (ALF) is a severe condition with a mortality rate up to 70%. Human enterovirus (HEV) infections are associated with serious diseases in newborns, including myocarditis, meningoencephalitis and, more rarely, ALF with a fulminant course. METHODS: Cases of neonatal-onset ALF were identified using the institutional clinical database. The history and clinical data of infants with HEV infection were collected by medical record revision. Viral testing by nested real- time PCR (nRT-PCR) was performed by the Bambino Gesù Children's Hospital Clinical Laboratory and by National Institute of Public Health in Rome. RESULTS: Among ten infants referred to our Institution with neonatal-onset ALF in the 2004-2018 period, we identified five cases due to HEV. In three of these, the mother reported an episode of mild fever and diarrhea during the last trimester of gestation, suggesting fetal-maternal transmission. All were late preterm infants (32-36 weeks). Two infants died as a result of ALF; the other three survived with full normalization of liver function. In four, the causing agents were coxsackie B serotypes 3 (n = 1), 4 (n = 1) and 5 (n = 2), in the fifth case we identified echovirus serotype 11. CONCLUSIONS: Human enterovirus (HEV) are a rare but relevant cause of ALF in neonates. HEV testing should be systematically performed in cases of neonatal ALF for diagnostic and management purposes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|