Histopathological study of encephalomalacia in neonatal calves and application of neuronal and axonal degeneration marker
| Autor: | Kenji Koyama, Akihisa Kangawa, Kenichi Watanabe, Noriyuki Horiuchi, Tomomi Ozawa, Natsuko Fukumoto, Yoshiyasu Kobayashi, Hisashi Inokuma |
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| Rok vydání: | 2018 |
| Předmět: |
Alzheimer precursor protein A4
Pathology medicine.medical_specialty Necrosis 040301 veterinary sciences Encephalopathy Ischemia Cattle Diseases Hippocampus 0403 veterinary science 03 medical and health sciences neonatal calf Encephalomalacia 0302 clinical medicine medicine Animals Hyaline Fluoro-Jade C ischemic/hypoxic encephalopathy Cerebral Cortex Neurons Full Paper General Veterinary business.industry Brain 04 agricultural and veterinary sciences medicine.disease Perinatal asphyxia medicine.anatomical_structure Animals Newborn nervous system Cerebral cortex Hypoxia-Ischemia Brain Cattle medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | The Journal of Veterinary Medical Science SC10201903200007 NARO成果DBr-pub C10201812190022_4964. |
| ISSN: | 1347-7439 0916-7250 |
| DOI: | 10.1292/jvms.18-0143 |
| Popis: | Five calves that had shown neurological symptoms within 9 days after birth were histopathologically diagnosed as encephalomalacia. Two calves showed bilateral laminar cerebrocortical necrosis and neuronal necrosis in the corpus striatum and hippocampus. Since the distributional pattern of the lesions was consistent with that of global ischemia in other species, the lesions were probably hypoxic/ischemic encephalopathy consistent with the history of dystocia and perinatal asphyxia. One calf also showed bilateral laminar cerebrocortical necrosis. However, the lesions were chronic ones, because the calf had survived for long time and necropsied at postnatal day 118. Additionally, the lesions did not involve the corpus striatum and hippocampus. The other two calves showed multifocal necrosis with vascular lesions characterized by fibrin thrombi, perivascular edema and perivascular hyaline droplets in the cerebral cortex, corpus striatum, thalamus, brain stem and cerebellum. Considering the age of onsets and histopathological appearance, it was possible that latter three calves were also hypoxic/ischemic encephalopathy, however, exact cause of them was not revealed. In all calves, degenerated/necrotic neurons showed positive reactions for Fluoro-Jade C and degenerated axons showed immunoreactivity for Alzheimer precursor protein A4. Therefore, these markers were applicable to examination of brain injury in neonatal calves. |
| Databáze: | OpenAIRE |
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