IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils
| Autor: | Shizuo Akira, Kouji Tominaga, Haruki Okamura, Kenji Nakanishi, Tomohiro Yoshimoto, William E. Paul, Katsuaki Hoshino, Hiroko Tsutsui |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
T-Lymphocytes
Bone Marrow Cells chemical and pharmacologic phenomena Immunoglobulin E Histamine Release Allergic inflammation Proinflammatory cytokine Mice chemistry.chemical_compound Th2 Cells parasitic diseases Hypersensitivity Animals Cells Cultured Interleukin 4 Strongylida Infections B-Lymphocytes Mice Inbred BALB C Interleukin-13 Multidisciplinary biology Interleukin-18 hemic and immune systems Biological Sciences Interleukin-12 Basophils chemistry Immunology Interleukin 13 biology.protein Interleukin 12 Female Interleukin-3 Interleukin-4 Nippostrongylus Natural killer cell activation Histamine |
| Zdroj: | Proceedings of the National Academy of Sciences. 96:13962-13966 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.96.24.13962 |
| Popis: | IL-18 is a proinflammatory cytokine that plays an important role in natural killer cell activation and T helper 1 (Th1) cell responses. Mast cells and basophils are major inducers and effectors of allergic inflammation. Here we show that basophils and mast cells derived by culture of bone marrow cells with IL-3 for 10 days express IL-18Rα chain and that basophils produce large amounts of IL-4 and IL-13 in response to stimulation with IL-3 and IL-18. Injection of IL-12 and IL-18 inhibits IgE production in helminth-infected wild-type mice and abolishes the capacity of their basophils to produce IL-4 and IL-13 in response to stimulation either with IL-3 and IL-18 or with FcɛR cross-linkage. By contrast, this combination of cytokines actually increases IgE levels in helminth-infected IFN-γ−/−mice and enhances IL-4 and IL-13 production by their basophils. Furthermore, injection of IL-18 alone enhances basophil production of IL-4 and histamine both in wild-type and IFN-γ−/−mice. Thus, IL-18 has the potential to stimulate basophils but, when given with IL-12, exhibits an antiallergic actionin vivo. |
| Databáze: | OpenAIRE |
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