Impact of higher doses of vitamin C in modulating pesticide genotoxicity
| Autor: | Parimal Kumar Khan, S. P. Sinha |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Vitamin
Male Health Toxicology and Mutagenesis Ascorbic Acid Pharmacology Toxicology medicine.disease_cause chemistry.chemical_compound Mice Genetics medicine Animals Pesticides Genetics (clinical) Micronuclei Chromosome-Defective Zineb Micronucleus Tests Vitamin C Dose-Response Relationship Drug Chemistry Phosphamidon Antimutagenic Agents Ascorbic acid Oncology Micronucleus test Maneb Female Micronucleus Antimutagen Genotoxicity Endosulfan |
| Zdroj: | Teratogenesis, carcinogenesis, and mutagenesis. 14(4) |
| ISSN: | 0270-3211 |
| Popis: | The modulatory effect of higher doses of vitamin C (ascorbic acid) on the genotoxicity of the three pesticides (endosulfan, phosphamidon, and mancozeb) was assessed in the in vivo micronucleus test in Swiss albino mice. Concurrent administration of the vitamin in a dose (20 mg/kg bwt/day) equivalent to double the human therapeutic one, along with each of the three pesticides, was most effective as an antimutagen. The therapeutic dose (10 mg/kg bwt/day) was comparatively less so, and the quadruple (40 mg/kg bwt/day) of it did not show any further amelioration. |
| Databáze: | OpenAIRE |
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