Vitamin D metabolites in spasmophilia
| Autor: | Sergio Ortolani, MA lannetta, G. G. Gandolini, M.P. Caraceni, F Campanini |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Calcitonin Male medicine.medical_specialty Tetany Metabolite chemistry.chemical_element Calcium chemistry.chemical_compound Vitamin D+Metabolites Internal medicine medicine Vitamin D and neurology Humans Vitamin D Aged Calcifediol Pharmacology Calcium metabolism General Medicine Metabolism Middle Aged Spasmophilia Endocrinology chemistry Female medicine.symptom |
| Zdroj: | Biomedicine & Pharmacotherapy. 44:479-482 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/0753-3322(90)90209-r |
| Popis: | The comparison of 20 untreated spasmophilic patients (2 men, 18 women) with 25 healthy subjects revealed no significant differences in vitamin D metabolite plasma levels or in other laboratory indexes of calcium metabolism except for ionized and cytosolic free calcium levels which were lower in the former group (P less than 0.01; P less than 0.001). After 3 months treatment with calcitonin and 25-hydroxyvitamin D there was a clear improvement in patient symptoms, no significant modification of 1,25-dihydroxyvitamin D levels and significant increases in 25-hydroxyvitamin D, cytosolic free calcium and urinary calcium (P less than 0.001, P less than 0.001 and P less than 0.01, respectively). We conclude that high plasma levels of 25-hydroxyvitamin D play an important role in restoring normal cytosolic free calcium levels and reducing clinical manifestations in spasmophilia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|