Re-Evaluating Simpson Grade I, II, and III Resections in Neurosurgical Treatment of World Health Organization Grade I Meningiomas
| Autor: | Laura Ruiz-Martin, Maria Gonzalez-Tablas, María Tabernero, Pablo Sousa, Daniel Pascual-Argente, Alvaro Otero-Rodríguez, Maria Cristina Munoz-Martin, Alberto Orfao |
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| Přispěvatelé: | Instituto de Investigación Biomédica de Salamanca |
| Rok vydání: | 2016 |
| Předmět: |
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medicine.medical_specialty Time Factors Tumor resection Simpson grade World Health Organization Complete resection Severity of Illness Index World health Disease-Free Survival Neurosurgical Procedures Meningioma 03 medical and health sciences 0302 clinical medicine Recurrence Surgical equipment Meningeal Neoplasms Medicine Humans Longitudinal Studies Total resection Aged Retrospective Studies business.industry Who grade Middle Aged Neurovascular bundle medicine.disease Tentorium Surgery 030220 oncology & carcinogenesis Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 1878-8769 |
| Popis: | [Background]: Since 1957, the Simpson grading system has been considered a predictive system for meningioma recurrence. However, since then, surgical equipment and neurosurgical technique have developed extensively, so this grading system should be re-evaluated. This study aims to assess if the recurrence rate and recurrence-free survival (RFS) are different after Simpson grade I, II, and III resections in World Health Organization (WHO) grade I meningiomas. [Methods]: We retrospectively reviewed the data of patients who underwent surgical treatment of WHO grade I meningiomas located in the convexity (group 1), falx/parasagittal (group 2), skull base, and tentorium (group 3) between June 1991 and December 2011. We compared the recurrence rates and RFSs between Simpson grade I, II, and III resections in both overall cases and tumor subsets according to their localization. [Results]: A total of 224 meningiomas were included in this study. There were no significant differences in recurrence rates and RFSs between Simpson grades I, II, and III. In each of the location groups, no significant differences were noted between the different degrees of Simpson. [Conclusions]: We have shown that complete resection of WHO grade I meningiomas achieves excellent tumor control, regardless of Simpson grades. More aggressive attempts at tumor resection (ie, Simpson grade I) must be balanced against the risks of removing dura or damaging critical neurovascular structures. This work was partially supported by grant “Project IB14/05 IBSAL” from Instituto Biosanitario de Salamanca. |
| Databáze: | OpenAIRE |
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