Immunoglobulin-Based Investigation of Spontaneous Resolution of Chlamydia trachomatis Infection
| Autor: | Christen G. Press, Sandra G. Morrison, Rakesh K. Bakshi, John R. Papp, Kanupriya Gupta, Rachel J. Gorwitz, Stephen J. Jordan, William M. Geisler, Ladraka' T. Brown, Jeannette Y. Lee, Richard P. Morrison |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine Adolescent Chlamydia trachomatis Enzyme-Linked Immunosorbent Assay medicine.disease_cause Young Adult 03 medical and health sciences 0302 clinical medicine Humans Immunology and Allergy Medicine 030212 general & internal medicine Chlamydia trachomatis infection Chlamydia biology business.industry Brief Report Chlamydia Infections medicine.disease Antibodies Bacterial Virology 030104 developmental biology Infectious Diseases Immunoglobulin G biology.protein Female Immunoglobulin G1 Antibody business Follow-Up Studies |
| Zdroj: | The Journal of Infectious Diseases. 215:1653-1656 |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Chlamydia trachomatis elementary body enzyme-linked immunosorbent assay (ELISA) was used to investigate serum anti-CT immunoglobulin G1 (IgG1; long-lived response) and immunoglobulin G3 (IgG3; short-lived response indicating more recent infection) from treatment (enrollment) and 6-month follow-up visits in 77 women previously classified as having spontaneous resolution of chlamydia. Of these women, 71.4% were IgG1+IgG3+, consistent with more recent chlamydia resolution. 15.6% were IgG3− at both visits, suggesting absence of recent chlamydia. Using elementary body ELISA, we demonstrated approximately 1 in 6 women classified as having spontaneous resolution of chlamydia might have been exposed to C. trachomatis but not infected. Further, we classified their possible infection stage. |
| Databáze: | OpenAIRE |
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