Ultraporous Polyquaternium-Carboxylated Chitosan Composite Hydrogel Spheres with Anticoagulant, Antibacterial, and Rapid Endotoxin Removal Profiles for Sepsis Treatment

Autor:	Xianda Liu, Tao Xu, Chunji Jiang, Yupei Li, Baihai Su, Weifeng Zhao, Changsheng Zhao
Rok vydání:	2022
Předmět:	Chitosan Staphylococcus aureus Polymers and Plastics Anticoagulants Hydrogels Bioengineering Anti-Bacterial Agents Endotoxins Biomaterials Sepsis Escherichia coli Materials Chemistry Humans Emulsions Adsorption
Zdroj:	Biomacromolecules. 23:3728-3742
ISSN:	1526-4602 1525-7797
DOI:	10.1021/acs.biomac.2c00583
Popis:	Hemoperfusion is an important method to remove endotoxins and save the lives of patients with sepsis. However, the current adsorbents for hemoperfusion have disadvantages of insufficient endotoxin adsorption capacity, poor blood compatibility, and so on. Herein, we proposed a novel emulsion templating (ET) method to prepare ultraporous and double-network carboxylated chitosan (CCS)-poly(diallyl dimethylammonium chloride) (PDDA) hydrogel spheres (ET-CCSPD), bearing both negative and positive charges. CCS was introduced to balance the strong positive charges of PDDA to improve hemocompatibility, and emulsion templates endowed the adsorbent with an ultraporous structure for enhanced adsorption efficacy. The ET-CCSPDs neither damaged blood cells nor activated complement responses. In addition, the activated partial thromboplastin time (APTT) was prolonged to 8.5 times, which was beneficial for reducing the injection of anticoagulant in patients. The ET-CCSPDs had excellent scavenging performance against bacteria and endotoxin, with removal ratios of 96.7% for
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b80b5c47ffcc75d2a140205a9298fc4 https://doi.org/10.1021/acs.biomac.2c00583 Zobrazit plný text záznamu