Solving the mystery of HBV-related mixed cryoglobulinemia: potential biomarkers of disease progression

Autor: Anna Linda Zignego, Laura Gragnani, Gabriele Ciasca, Annunziata Stefanile, Francesca Gulli, Krizia Pocino, Umberto Basile, Cecilia Napodano, Serena Lorini, Stefania Colantuono, Antonella Barini, Luca Miele, Mariapaola Marino, Marcella Visentini, Lorenzo Vantaggio, Silvia Marri, Milvia Casato, Gian Ludovico Rapaccini
Rok vydání: 2021
Předmět:
Male
0301 basic medicine
Immunoglobulin A
medicine.disease_cause
vasculitis
Immunoglobulin G
Settore MED/05 - PATOLOGIA CLINICA
rheumatoid factor
Settore BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA
0302 clinical medicine
Mixed Cryoglobulinemia
HBV
Medicine
Pharmacology (medical)
AcademicSubjects/MED00360
Aged
80 and over
biology
Middle Aged
Cryoglobulinemia
Disease Progression
Female
Original Article
030211 gastroenterology & hepatology
HBV
mixed cryoglobulinemia
vasculitis
free light chains
IgG subclasses
rheumatoid factor
Vasculitis
Adult
Hepatitis B virus
Settore MED/12 - GASTROENTEROLOGIA
Cryoglobulins
03 medical and health sciences
Rheumatology
Humans
Rheumatoid factor
IgG subclasses
Pandemics
Aged
Retrospective Studies
SARS-CoV-2
business.industry
COVID-19
medicine.disease
030104 developmental biology
Free Light chains
Immunoglobulin M
Immunology
biology.protein
business
Biomarkers
Zdroj: Rheumatology (Oxford, England)
ISSN: 1462-0332
1462-0324
Popis: Objectives The biomarkers of an immunological dysregulation due to a chronic HBV infection are indeed understudied. If untreated, this condition may evolve into liver impairment co-occurring with extrahepatic involvements. Here, we aim to identify a new panel of biomarkers [including immunoglobulin G (IgG) subclasses, RF, and Free Light Chains (FLCs)] that may be useful and reliable for clinical evaluation of HBV-related cryoglobulinemia. Methods We retrospectively analysed clinical data from 44 HBV-positive patients. The patients were stratified (according to the presence/absence of mixed cryoglobulinemia) into two groups: 22 with cryoglobulins (CGs) and 22 without CGs. Samples from 20 healthy blood donors (HDs) were used as negative controls. Serum samples were tested for IgG subclasses, RF (-IgM, -IgG, and -IgA type), and FLCs. Results We detected a strikingly different distribution of serum IgG subclasses between HDs and HBV-positive patients, together with different RF isotypes; in addition, FLCs were significantly increased in HBV-positive patients compared with HDs, while no significant difference was shown between HBV-positive patients with/without mixed cryoglobulinemia. Conclusion The immune-inflammatory response triggered by HBV may be monitored by a peculiar profile of biomarkers. Our results open a new perspective in the precision medicine era; in these challenging times, they could also be employed to monitor the clinical course of those COVID-19 patients who are at high risk of HBV reactivation due to liver impairment and/or immunosuppressive therapies.
Databáze: OpenAIRE
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