Rapid Improvement in Jaundice Using Transdermal Isosorbide Tape as a Nitric Oxide Donor in Two Adult Patients with Transplantation-associated Microangiopathy Related to Graft-versus-host Disease
| Autor: | Keijiro Sato, Hidetoshi Satomi, Toshimitsu Ueki, Hikaru Kobayashi, Mayumi Ueno, Yuki Hiroshima, Naoaki Ichikawa, Masahiko Sumi |
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| Rok vydání: | 2022 |
| Předmět: |
Adult
medicine.medical_specialty Isosorbide Graft vs Host Disease Jaundice Gastroenterology Nitric oxide chemistry.chemical_compound Internal medicine Internal Medicine Humans Transplantation Homologous Medicine Nitric Oxide Donors Vascular Diseases Transdermal Acute leukemia business.industry Microangiopathy Hematopoietic Stem Cell Transplantation General Medicine medicine.disease Transplantation surgical procedures operative Graft-versus-host disease chemistry medicine.symptom business medicine.drug |
| Zdroj: | Internal Medicine. 61:1225-1230 |
| ISSN: | 1349-7235 0918-2918 |
| DOI: | 10.2169/internalmedicine.7789-21 |
| Popis: | Two adult patients with acute leukemia developed transplantation-associated microangiopathy (TAM) related to graft-versus-host disease (GVHD). Both patients were resistant to standard therapy for TAM and GVHD, which led to markedly elevated serum total bilirubin levels of 47.5 and 10.6 mg/dL, respectively. Transdermal isosorbide tape as a nitric oxide donor was applied to Patients 1 and 2 on post-transplantation days 60 and 66, respectively, which rapidly improved their jaundice after 1 day. This is the first report to describe the efficacy of transdermal isosorbide tape for adult patients with jaundice associated with TAM related to GVHD. |
| Databáze: | OpenAIRE |
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