The molecular organization of the Antennapedia locus of drosophila
| Autor: | Matthew P. Scott, Amy J. Weiner, Franco Scalenghe, Barry Polisky, Tulle I. Hazelrigg, Thomas C. Kaufman, Vincenzo Pirrotta |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Genetics
Transcription Genetic fungi Chromosome Mapping Locus (genetics) Thorax Biology Molecular cloning Antennapedia General Biochemistry Genetics and Molecular Biology Exon chemistry.chemical_compound Drosophila melanogaster Gene Expression Regulation chemistry Transcription (biology) RNA Messenger Cloning Molecular Homeotic gene Gene Alleles DNA Genes Dominant |
| Zdroj: | Cell. 35:763-776 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/0092-8674(83)90109-5 |
| Popis: | The Antennapedia complex (ANT-C) of Drosophila is a cluster of genes involved in the regulation of morphogenesis, including at least three homoeotic loci (Antp, Scr, and pb), in which mutations cause switches of cell fates from one developmental pathway to another. We have isolated DNA clones containing most of the ANT-C, a region of about 300 kb. Antp mutations are distributed across more than 100 kb of the ANT-C. Dominant Antp mutations are associated with certain chromosome rearrangements and insertions that interrupt the 100 kb region; other chromosome breaks within the region cause recessive lethality and have no dominant effects. Two prominent transcripts (3.5 and 5.0 kb) are derived from exons within and at the two ends of the 100 kb region. |
| Databáze: | OpenAIRE |
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