Evidence-based oral antiplatelet therapy among hospitalized Chinese patients with acute myocardial infarction: results from the Chinese acute myocardial infarction registry

Autor: Runlin Gao, Xueyan Zhao, Zhifang Wang, Jingang Yang, Yuejin Yang, Jinqing Yuan, Zhan Gao, Shubin Qiao, Xiao-Fang Tang, Lifu Liu
Rok vydání: 2021
Předmět:
Male
Time Factors
Administration
Oral
030204 cardiovascular system & hematology
0302 clinical medicine
030212 general & internal medicine
Myocardial infarction
Prospective Studies
Registries
Practice Patterns
Physicians'
Non-ST Elevated Myocardial Infarction
Aspirin
Evidence-Based Medicine
Dual Anti-Platelet Therapy
Middle Aged
Clopidogrel
Cardiac surgery
Hospitalization
Treatment Outcome
Oral antiplatelet therapy
Female
Cardiology and Cardiovascular Medicine
medicine.drug
medicine.medical_specialty
China
Acute myocardial infarction
Loading dose
03 medical and health sciences
Percutaneous Coronary Intervention
Internal medicine
medicine
Diseases of the circulatory (Cardiovascular) system
Humans
cardiovascular diseases
Healthcare Disparities
P2Y12 inhibitors
Angiology
Aged
business.industry
Research
Guideline
medicine.disease
Drug Utilization
RC666-701
Conventional PCI
Purinergic P2Y Receptor Antagonists
ST Elevation Myocardial Infarction
business
Platelet Aggregation Inhibitors
Zdroj: BMC Cardiovascular Disorders
BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-12 (2021)
ISSN: 1471-2261
Popis: Background Oral antiplatelet therapy is the cornerstone of treatment for acute myocardial infaction (AMI). However, detailed usage data on oral antiplatelet therapy are lacking. Methods Using data from a nationally representative sample of patients with AMI, the detailed usage of oral antiplatelet therapy was analyzed in 40,202 consecutive eligible patients. Results The proportions of patients with AMI taking loading doses of aspirin and P2Y12 inhibitors were relatively low (62.2% and 63.6%, respectively), whereas approximately 90% of patients received maintenance doses of aspirin, P2Y12 inhibitors, and dual antiplatelet therapy. The proportions of patients taking loading doses of aspirin and P2Y12 inhibitors gradually decreased with age. Male sex, an educational level of at least college, an interval from onset to treatment of P P Conclusions The proportion of patients with AMI receiving loading doses of aspirin and P2Y12 inhibitors during hospitalization was relatively low, and this rate was affected by many factors, such as age, sex, educational level, region of residence, and the interval from onset to treatment. The underutilization of guideline-based P2Y12 inhibitors was also problematic. Hence, quality improvement initiatives are needed to enhance adherence to guidelines to improve consistent use of oral antiplatelet therapy. Trial registration The Chinese Acute Myocardial Infarction Registry; Trial registration number: ChiCTR-ONC-12002636; Registered 31 October 2012; http://www.chictr.org.cn/showproj.aspx?proj=6916
Databáze: OpenAIRE
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