| Autor: |
Assunta Cirella, Carlos Luri-Rey, Claudia Augusta Di Trani, Alvaro Teijeira, Irene Olivera, Elixabet Bolaños, Eduardo Castañón, Belen Palencia, Davide Brocco, Myriam Fernández-Sendin, Fernando Aranda, Pedro Berraondo, Ignacio Melero |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Pharmacology & Therapeutics |
| ISSN: |
0163-7258 |
| DOI: |
10.1016/j.pharmthera.2022.108189 |
| Popis: |
Interleukin-12 is considered a potent agent to enhance antitumor immune responses. It belongs to a family of heterodimeric cytokines with key roles in the up-regulation and down-regulation of cellular immunity. Since its discovery, recombinant IL-12 was found to exert potent antitumor effects in rodent tumor models and was rapidly tested in the clinic with an unfavorable benefit/toxicity profile. Localized delivery of IL-12 dramatically improves the therapeutic index and this approach is being applied in the clinic based on in-vivo electroporation of naked plasmid DNA encoding IL-12, mRNA formulations, viral vectors and tumor-targeted fusion proteins. Other biotechnology strategies such as IL-12-engineered local adoptive cell therapy and pro-cytokines can also be used to improve results and broaden the therapeutic window. Combination strategies of such localized IL-12-based approaches with checkpoint inhibitors are yielding promising results both preclinically and in the early-phase clinical trials. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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Full Text from ScienceDirect