Myocardial removal of free fatty acids under normal and pathological conditions
| Autor: | John J. Spitzer, L. J. Finkelstein, John C. Scott |
|---|---|
| Rok vydání: | 1962 |
| Předmět: |
Atropine
Arteriovenous difference medicine.medical_specialty medicine.medical_treatment Fatty Acids Nonesterified Diabetes Mellitus Experimental Norepinephrine (medication) Norepinephrine Physiology (medical) Internal medicine Animals Humans Medicine O2 consumption Hypoxia Pathological business.industry Myocardium Insulin Fatty Acids Hypoxia (medical) Lipid Metabolism Endocrinology Alloxan diabetes lipids (amino acids peptides and proteins) medicine.symptom business hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | American Journal of Physiology-Legacy Content. 203:482-486 |
| ISSN: | 0002-9513 |
| DOI: | 10.1152/ajplegacy.1962.203.3.482 |
| Popis: | Myocardial arteriovenous difference in free fatty acids (FFA) and coronary flow was determined in dogs under morphine-chloralose anesthesia. Fifteen minutes after the administration of insulin the A-V difference decreased. FFA uptake did not change significantly. Alloxan diabetes decreased the utilization per cent of FFA. Norepinephrine elevated myocardial uptake and arterial FFA. Hypoxia did not change FFA uptake. Hypothyroidism lowered myocardial uptake. Left ventricular O2 consumption increased after administration of atropine in both normal and hypothyroid animals, whereas hypothyroidism was associated with a decreased value. A significant correlation was found in normal dogs between arterial FFA concentration and myocardial uptake. A different relationship suggested itself in hypothyroid animals. A correlation was also shown between the per cent of myocardial O2 consumption calculated for complete oxidation of FFA and the myocardial R.Q. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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