Earliest Time to Onset of Action Leading to Successful Intercourse with Vardenafil Determined in an At‐Home Setting: A Randomized, Double‐Blind, Placebo‐Controlled Trial
| Autor: | Manfred Beneke, Hartwig Schwaibold, Harin Padma-Nathan, Tiemo-Joerg Bandel, Hartmut Porst, Ernst Ulbrich, Jacques Buvat, Francesco Montorsi |
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| Přispěvatelé: | Montorsi, Francesco, Padma Nathan, Harin, Buvat, Jacque, Schwaibold, Hartwig, Beneke, Manfred, Ulbrich, Ernst, Bandel Tiemo, Joerg, Porst, Hartmut |
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Phosphodiesterase Inhibitors Sexual Behavior Urology Endocrinology Diabetes and Metabolism Placebo-controlled study Placebo Piperazines law.invention Placebos Endocrinology Double-Blind Method Erectile Dysfunction Vardenafil Dihydrochloride Randomized controlled trial law Internal medicine Flushing medicine Humans Prospective Studies Sulfones Dosing Dose-Response Relationship Drug Triazines business.industry Coitus Headache Imidazoles Middle Aged medicine.disease Surgery Psychiatry and Mental health Sexual intercourse Treatment Outcome Erectile dysfunction Reproductive Medicine Vardenafil Onset of action business medicine.drug |
| Zdroj: | The Journal of Sexual Medicine. 1:168-178 |
| ISSN: | 1743-6095 |
| DOI: | 10.1111/j.1743-6109.2004.04025.x |
| Popis: | Introduction. Vardenafil, a potent and selective oral PDE5 inhibitor, is efficacious and generally well-tolerated in men with erectile dysfunction (ED). Of considerable interest to patients and physicians is an understanding of the time required after dosing to attain penile erection sufficient for successful sexual intercourse. Aim. To determine the earliest time to onset of action of vardenafil 10 and 20 mg leading to successful intercourse compared to placebo in men with ED. Methods. A prospective, randomized, double-blind, parallel-group, at-home study of 732 men with ED (mean age 55.5 years) was conducted at 64 sites in North America and Europe. Following a 4-week run-in period, patients were randomized to either vardenafil 10 (N = 237) or 20 mg (N = 248) or placebo (N = 247) to be taken on demand over 4 weeks. Using a stopwatch, patients recorded the elapsed time from dosing to attainment of an erection perceived to be adequate for penetration that led to intercourse completion. Earliest time of onset was defined as the fastest time among the first four doses for each patient. Time points from 25 to 5 minutes were tested for significance (alpha = 0.02 5) using a backward stepping procedure. Results. Mean baseline erectile function domain score (13.4) indicated moderate ED. Within 25 minutes after dosing, 50%/53% of men on vardenafil 10/20 mg had at least one erection in the first four doses perceived to be sufficient for penetration with subsequent intercourse completion compared to 26% on placebo (P < 0.0001). A statistically superior response to vardenafil vs. placebo was observed in these responders at all times >= 10 and >= 11 minutes (P < 0.025) in the 10 and 20 mg groups, respectively. In a retrospective analysis using time intervals of |
| Databáze: | OpenAIRE |
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