Luminal nitric oxide in ileal reservoirs for continent cutaneous diversion or orthotopic bladder reconstruction
| Autor: | Kjell-Arne Ung, Anna-Carin Olin, David Pazooki, Harriet Törnqvist, Anders Kilander, Olof Jonsson, Elisabet Lindholm |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Pathology Bacteriuria Urology Urinary system Colony Count Microbial Colonic Pouches Ileum Urine Nitric Oxide Gastroenterology Nitric oxide Kock pouch chemistry.chemical_compound Nephelometry and Turbidimetry Internal medicine medicine Humans Urinary bladder biology Bacteria business.industry Air C-reactive protein Urinary Reservoirs Continent Urinary Bladder Diseases Middle Aged medicine.disease medicine.anatomical_structure C-Reactive Protein chemistry Luminescent Measurements biology.protein Female business |
| Zdroj: | European urology. 48(1) |
| ISSN: | 0302-2838 |
| Popis: | Objectives: To measure mucosal inflammation as reflected in nitric oxide (NO) production in ileal reservoirs for the storage of urine and to correlate it with the growth of bacteria as well as CRP. Methods: Intraluminal gas NO concentrations were determined using the chemoluminescence technique in 25 patients with continent cutaneous ileal reservoirs (Kock pouch) and 12 patients with orthotopic bladders (hemi-Kock or T-pouch). NO concentrations were determined in both intestinal reservoir gas and silicon catheter balloon gas. Urinary culture and blood CRP determinations were performed. Results: NO concentrations in reservoir gas were higher than in silicon catheter balloons. Bacteriuria was associated with approximately 20 times higher NO concentrations than sterile urine. NO concentrations did not differ between continent cutaneous reservoirs or orthotopic bladders when due attention was paid to variance in the rate of bacteriuria. Elevated CRP was associated with higher NO concentrations. Bacteriuria with acinetobacter, enterococci and pseudomonas appeared to cause comparatively lower NO concentrations. The inflammatory response of reservoir walls to bacteriuria did not decrease with time. Conclusions: Urine in itself causes much less intestinal wall inflammation than bacteriuria, as reflected in NO production. High CRP values are associated with high NO concentrations. The inflammatory response varies with the bacterial specimens. |
| Databáze: | OpenAIRE |
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