A Genome-wide Association Study of Lung Cancer Identifies a Region of Chromosome 5p15 Associated with Risk for Adenocarcinoma
| Autor: | James McKay, Neil E. Caporaso, Jarmo Virtamo, Lars J. Vatten, Heike Bickeböller, Egil Arnesen, Christine Bouchard, Sharon A. Savage, Dario Consonni, Rayjean J. Hung, Yufei Wang, Simone Benhamou, Ryan Diver, Angela Cecilia Pesatori, John R. McLaughlin, Demetrius Albanes, Hans E. Krokan, Melissa Rotunno, Andrew W. Bergen, Stephen J. Chanock, Kari Stefansson, Qizhai Li, Elizabeth W. Pugh, Meredith Yeager, H.-Erich Wichmann, Kai Yu, Michael J. Thun, Alisa M. Goldstein, Patrick Sulem, Laurie Burdette, Albert Rosenberger, Thorunn Rafnar, Sholom Wacholder, Mari Nelis, Tõnu Vooder, Kevin B. Jacobs, Gudmar Thorleifsson, Christopher I. Amos, Richard S. Houlston, Angela Risch, Joseph F. Fraumeni, Valerie Gaborieau, Timothy Eisen, Wiebke Sauter, Ming-Sound Tsao, Paul Brennan, Lynn R. Goldin, Zhaoming Wang, Cathy C. Laurie, Gary E. Goodman, Kimberly F. Doheny, Margaret A. Tucker, Kristian Välk, Jenny Chang-Claude, Frank Skorpen, John K. Field, Chu Chen, Margaret R. Spitz, Ying Wang, Lisa Mirabello, Martin M. Oken, Maria Teresa Landi, Nilanjan Chatterjee, Pier Alberto Bertazzi, William Wheeler, Andres Metsapalu, Mark Lathrop |
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| Rok vydání: | 2009 |
| Předmět: |
Oncology
medicine.medical_specialty Lung Neoplasms Genotype Population Genome-wide association study Adenocarcinoma Biology Polymorphism Single Nucleotide Linkage Disequilibrium White People Cohort Studies 03 medical and health sciences 0302 clinical medicine Meta-Analysis as Topic Risk Factors Report Internal medicine Odds Ratio Genetics medicine Humans Genetics(clinical) Genetic Predisposition to Disease education Lung cancer Genetics (clinical) 030304 developmental biology 0303 health sciences education.field_of_study Case-control study Chromosome Genetic Variation Cancer Odds ratio medicine.disease Lung cancer susceptibility Human genetics 3. Good health Case-Control Studies 030220 oncology & carcinogenesis Chromosomes Human Pair 5 Erratum Genome-Wide Association Study |
| Zdroj: | Europe PubMed Central |
| ISSN: | 0002-9297 |
| DOI: | 10.1016/j.ajhg.2009.09.012 |
| Popis: | Three genetic loci for lung cancer risk have been identified by genome-wide association studies (GWAS), but inherited susceptibility to specific histologic types of lung cancer is not well established. We conducted a GWAS of lung cancer and its major histologic types, genotyping 515,922 single-nucleotide polymorphisms (SNPs) in 5739 lung cancer cases and 5848 controls from one population-based case-control study and three cohort studies. Results were combined with summary data from ten additional studies, for a total of 13,300 cases and 19,666 controls of European descent. Four studies also provided histology data for replication, resulting in 3333 adenocarcinomas (AD), 2589 squamous cell carcinomas (SQ), and 1418 small cell carcinomas (SC). In analyses by histology, rs2736100 (TERT), on chromosome 5p15.33, was associated with risk of adenocarcinoma (odds ratio [OR] = 1.23, 95% confidence interval [CI] = 1.13–1.33, p = 3.02 × 10−7), but not with other histologic types (OR = 1.01, p = 0.84 and OR = 1.00, p = 0.93 for SQ and SC, respectively). This finding was confirmed in each replication study and overall meta-analysis (OR = 1.24, 95% CI = 1.17–1.31, p = 3.74 × 10−14 for AD; OR = 0.99, p = 0.69 and OR = 0.97, p = 0.48 for SQ and SC, respectively). Other previously reported association signals on 15q25 and 6p21 were also refined, but no additional loci reached genome-wide significance. In conclusion, a lung cancer GWAS identified a distinct hereditary contribution to adenocarcinoma. |
| Databáze: | OpenAIRE |
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