PARP1-Erk synergism in proliferating cells
| Autor: | Leonid Visochek, Malka Cohen-Armon |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
MAPK/ERK pathway c-Fos Mouse embryonic fibroblasts Mechanism (biology) PARP1-dependent Erk activity Stimulation Biology Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine PARP1 Oncology Synaptic plasticity Gene expression PARP1-Erk binding biology.protein Immediate early gene 030217 neurology & neurosurgery Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| DOI: | 10.18632/oncotarget.25633 |
| Popis: | A synergism between PARP1 and phosphorylated Erk mediating IEG (immediate early gene) expression has been recently reported in cerebral neurons and cardiomyocytes. Stimulation induced PARP-Erk synergism was required for IEG expression underlying synaptic plasticity and long-term memory acquisition during learning. It was similarly required for cardiomyocytes development. Here, we identified this mechanism in Erk-induced gene expression promoting proliferation. This mechanism can be targeted in malignant cells. |
| Databáze: | OpenAIRE |
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