Depression-like behavior is dependent on age in male SAMP8 mice
| Autor: | Mercè Pallàs, David Pubill, Elena Escubedo, M. T. Rodrigo, Jorge Camarasa, Antoni Camins, David Pérez-Cáceres, Andrés Ciudad-Roberts |
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| Přispěvatelé: | Universitat de Barcelona |
| Rok vydání: | 2013 |
| Předmět: |
Male
Senescence Imipramine medicine.medical_specialty Aging Ratolins (Animals de laboratori) Dopamine Mice Inbred Strains Antidepressive Agents Tricyclic Tryptophan Hydroxylase Biology Mice Envelliment Internal medicine medicine Animals Depressió psíquica Receptor Swimming Cerebral Cortex Etologia Behavior Animal TPH2 Depression Incidence Malalties neurodegeneratives Neurodegenerative Diseases Alzheimer's disease Disease Models Animal Treatment Outcome Malaltia d'Alzheimer Endocrinology Mental depression Mice (Laboratory animals) Receptors Serotonin Dexamethasone suppression test Serotonin Geriatrics and Gerontology Gerontology Animal behavior Behavioural despair test medicine.drug |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Recercat. Dipósit de la Recerca de Catalunya instname |
| Popis: | Aging is associated with an increased risk of depression in humans. To elucidate the underlying mechanisms of depression and its dependence on aging, here we study signs of depression in male SAMP8 mice. For this purpose, we used the forced swimming test (FST). The total floating time in the FST was greater in SAMP8 than in SAMR1 mice at 9 months of age; however, this difference was not observed in 12-month-old mice, when both strains are considered elderly. Of the two strains, only the SAMP8 animals responded to imipramine treatment. We also applied the dexamethasone suppression test (DST) and studied changes in the dopamine and serotonin (5-HT) uptake systems, the 5-HT2a/2c receptor density in the cortex, and levels of TPH2. The DST showed a significant difference between SAMR1 and SAMP8 mice at old age. SAMP8 exhibits an increase in 5-HT transporter density, with slight changes in 5-HT2a/2c receptor density. In conclusion, SAMP8 mice presented depression-like behavior that is dependent on senescence process, because it differs from SAMR1, senescence resistant strain. |
| Databáze: | OpenAIRE |
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