An energy-restricted high-protein diet supplemented with β-cryptoxanthin alleviated oxidative stress and inflammation in nonalcoholic fatty liver disease: a randomized controlled trial

Autor: Bizhan Helli, Seyed Saeed Seyedian, Fatemeh Haidari, Abdollah Hojhabrimanesh, Kambiz Ahmadi-Angali
Rok vydání: 2020
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Beta-Cryptoxanthin
Population
030209 endocrinology & metabolism
High-protein diet
Iran
medicine.disease_cause
Gastroenterology
law.invention
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Double-Blind Method
Randomized controlled trial
Non-alcoholic Fatty Liver Disease
law
Internal medicine
Nonalcoholic fatty liver disease
medicine
Humans
Outpatient clinic
education
Caloric Restriction
Inflammation
education.field_of_study
030109 nutrition & dietetics
Nutrition and Dietetics
Adiponectin
business.industry
Provitamins
Malondialdehyde
medicine.disease
Combined Modality Therapy
Oxidative Stress
Treatment Outcome
chemistry
Dietary Supplements
Diet
High-Protein
Female
business
Biomarkers
Oxidative stress
Zdroj: Nutrition Research. 73:15-26
ISSN: 0271-5317
Popis: The efficacy of β-cryptoxanthin (BCX), a high-protein diet (HPD), or both in reducing oxidative stress and inflammation in nonalcoholic fatty liver disease (NAFLD) has never been examined within a randomized controlled trial (RCT). Thus, we aimed to assess the efficacy of an energy-restricted HPD supplemented with BCX in alleviating these conditions in NAFLD in an RCT design. We hypothesized that this combination may improve oxidative stress and inflammation in NAFLD as compared to a standard energy-restricted diet. Ninety-two ultrasonographically confirmed overweight/obese adult NAFLD patients attending an outpatient clinic in Ahvaz, Iran, were recruited for this 12-week, single-center, parallel-group, double-blind RCT from 2017 to 2018. Subjects were randomized into 4 equal groups (n = 23): HPD-BCX (energy-restricted HPD + BCX), HPD (energy-restricted HPD + placebo), BCX (standard energy-restricted diet + BCX), and control (standard energy-restricted diet + placebo). Serum levels of oxidative stress- and inflammation-related markers, as primary outcome measures, were determined at baseline and at the study end point. The 1-way analysis of covariance models in the intention-to-treat population (N = 92) showed that the HPD-BCX group achieved greater 12-week reductions in malondialdehyde, high-sensitivity C-reactive protein, interleukin-6, and total cytokeratin-18 (CK18-M65) but higher increases in total antioxidant capacity and adiponectin compared to the control group (mean differences for malondialdehyde, high-sensitivity C-reactive protein, interleukin-6, total cytokeratin-18, total antioxidant capacity, and adiponectin were -1.9 nmol/mL, -1.0 mg/L, -2.0 ng/L, -270.9 ng/L, 2.5 U/mL, and 1.9 mg/L, respectively; all P .001). These results show that an energy-restricted HPD supplemented with BCX more efficaciously alleviates oxidative stress and inflammation in NAFLD as compared to a standard energy-restricted diet.
Databáze: OpenAIRE
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