Effects of a metallic implant on radiotherapy planning treatment—experience on a human cadaver
| Autor: | Georges Noël, Alicia Thiery, Ziad El Bitar, Delphine Antoni, I. Menoux, David Brinkert, Florent Kuntz, Robin Fabbro, Clara Le Fèvre |
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| Přispěvatelé: | Institut de Cancérologie Strasbourg (ICANS), Département Recherches Subatomiques (DRS-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Hôpital de Hautepierre [Strasbourg], AERIAL ILLKIRCH FRA, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_treatment
Context (language use) [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine Alanine dosimeter radiation therapy Tomotherapy Cadaver medicine Humans Dosimetry Radiation treatment planning Human cadaver metallic implant (MI) Dosimeter dosimetry business.industry human cadaver Soft tissue General Medicine 3. Good health Radiation therapy Oncology [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph] Radiotherapy Intensity-Modulated Nuclear medicine business |
| Zdroj: | Chinese Clinical Oncology Chinese Clinical Oncology, AME Publishing Company, 2020, 9 (2), pp.14. ⟨10.21037/cco.2020.01.09⟩ |
| ISSN: | 2304-3865 2304-3873 |
| DOI: | 10.21037/cco.2020.01.09⟩ |
| Popis: | International audience; Background: Metallic implants (MIs) complicate radiotherapy planning. Several studies have worked on tissue-equivalent phantoms as experimental models to estimate dose distributions in this context. The application of these results to clinical practice remains disputable because the inhomogeneity of human tissue densities is a difficult factor to integrate into dose calculation software. In this work, we evaluate the impact of human tissue inhomogeneities by assessing the discrepancies between treatment planning system (TPS) dose calculations and measured delivered doses on a human cadaver with hip prostheses.Methods: A total of 143 alanine dosimeters were positioned in contact with the prostheses (bones group), soft tissues (soft tissues group), skin surfaces (skin group) and natural cavities (cavities group) of a human cadaver. The planning target volume (PTV) corresponded to a standard endometrial cancer treatment. The irradiation was performed with 6 MV X-ray tomotherapy at the one fraction-dose of 10 Gy.Results: A total of 140 dosimeters were analyzed. After applying a temperature correction coefficient to the measured doses, the global analysis of all dosimeters showed a significant difference between the calculated doses and the measured doses (P |
| Databáze: | OpenAIRE |
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