Current Perspectives on Therapies, Including Drug Delivery Systems, for Managing Glioblastoma Multiforme
Autor: | Vishakante Gowda Devegowda, Muthuraman Arunachalam, Thirumalaraju Vaishnavi, Amruthesh C. Shivachar, Rohit Rajendra Bhosale, Vishal Kumar Gupta, Mahendran Bhaskaran |
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Rok vydání: | 2020 |
Předmět: |
Adult
medicine.medical_specialty Physiology Cognitive Neuroscience medicine.medical_treatment Malignant brain tumor Biochemistry Central Nervous System Neoplasms 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine medicine Humans Intensive care medicine 030304 developmental biology 0303 health sciences Brain Neoplasms business.industry Molecular pathology Cancer Treatment options Cell Biology General Medicine medicine.disease Radiation therapy Drug delivery Glioblastoma business 030217 neurology & neurosurgery Cell signaling pathways |
Zdroj: | ACS Chemical Neuroscience. 11:2962-2977 |
ISSN: | 1948-7193 |
Popis: | Glioblastoma multiforme (GBM), a standout among the most dangerous class of central nervous system (CNS) cancer, is most common and is an aggressive malignant brain tumor in adults. In spite of developments in modality therapy, it remains mostly incurable. Consequently, the need for novel systems, strategies, or therapeutic approaches for enhancing the assortment of active agents meant for GBM becomes an important criterion. Currently, cancer research focuses mainly on improving the treatment of GBM via diverse novel drug delivery systems. The treatment options at diagnosis are multimodal and include radiation therapy. Moreover, significant advances in understanding the molecular pathology of GBM and associated cell signaling pathways have opened opportunities for new therapies. Innovative treatment such as immunotherapy also gives hope for enhanced survival. The objective of this work was to collect and report the recent research findings to manage GBM. The present review includes existing novel drug delivery systems and therapies intended for managing GBM. Reported novel drug delivery systems and diverse therapies seem to be precise, secure, and relatively effective, which could lead to a new track for the obliteration of GBM. |
Databáze: | OpenAIRE |
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