Vasodilator Effects of Ibudilast on Retinal Blood Vessels in Anesthetized Rats
| Autor: | Tsutomu Nakahara, Kenji Sakamoto, Masahiro Noguchi, Kunio Ishii, Asami Mori |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Pyridines Vasodilator Agents Pharmaceutical Science Ibudilast Vasodilation Thiobutabarbital Pharmacology chemistry.chemical_compound In vivo Heart rate medicine Animals Anesthesia Rats Wistar biology business.industry Retinal Vessels Prostanoid Retinal General Medicine Rats chemistry biology.protein Cyclooxygenase business medicine.drug |
| Zdroj: | Biological and Pharmaceutical Bulletin. 32:1924-1927 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.32.1924 |
| Popis: | Ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine) is clinically used as a cerebral vasodilator in Japan. However, the effects of ibudilast on retinal blood vessels have not been fully examined. The aim of this study, therefore, was to examine the effects of ibudilast on retinal blood vessels in rats in vivo. Male Wistar rats (8 to 10 weeks old) were anesthetized with thiobutabarbital (120 mg/kg, intraperitoneally (i.p.)). Retinal vascular images were captured with a fundus camera system for small animals, and the diameter of retinal blood vessels was measured. Ibudilast (0.1 and 1 mg/kg, intravenously (i.v.)) elicited a sustained increase in the diameter of retinal blood vessels and heart rate without altering systemic blood pressure. The effects of ibudilast were significantly reduced by treatment with the nonselective cyclooxygenase inhibitor indomethacin (5 mg/kg, i.p.). These results suggest that ibudilast dilates retinal blood vessels through cyclooxygenase-dependent mechanisms in rats in vivo. |
| Databáze: | OpenAIRE |
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