Recent advances in construction of small molecule-based fluorophore-drug conjugates
| Autor: | Shao Q. Yao, Linghui Qian, Jingyan Ge, Shubo Du, Wenjie Lang, Chaonan Yuan, Liquan Zhu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Drug
Fluorescent monitoring Cleavable linker Fluorophore media_common.quotation_subject Pharmaceutical Science Nanotechnology 02 engineering and technology Pharmacy 01 natural sciences Analytical Chemistry chemistry.chemical_compound Drug Discovery Electrochemistry Prodrug Spectroscopy media_common Review Paper Drug discovery 010401 analytical chemistry lcsh:RM1-950 021001 nanoscience & nanotechnology Small molecule 0104 chemical sciences lcsh:Therapeutics. Pharmacology chemistry Drug delivery Molecular imaging 0210 nano-technology Conjugate |
| Zdroj: | Journal of Pharmaceutical Analysis, Vol 10, Iss 5, Pp 434-443 (2020) Journal of Pharmaceutical Analysis |
| ISSN: | 2095-1779 |
| Popis: | As a powerful tool to advance drug discovery, molecular imaging may provide new insights into the process of drug effect and therapy at cellular and molecular levels. When compared with other detection methods, fluorescence-based strategies are highly attractive and can be used to illuminate pathways of drugs’ transport, with multi-color capacity, high specificity and good sensitivity. The conjugates of fluorescent molecules and therapeutic agents create exciting avenues for real-time monitoring of drug delivery and distribution, both in vitro and in vivo. In this short review, we discuss recent developments of small molecule-based fluorophore-drug conjugates, including non-cleavable and cleavable ones, that are capable of visualizing drug delivery. Graphical abstract To create your abstract, type over the instructions in the template box below. Fonts or abstract dimensions should not be changed or altered.Image 1 Highlights • Different types of fluorophore-drug conjugates are described. • Fluorophore-drug conjugates are widely used in monitoring drug delivery. • Prodrug based delivery systems are attractive using cleavable linkers. |
| Databáze: | OpenAIRE |
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