STAT6 expression in spindle cell lesions of the breast: An immunohistochemical study of 48 cases
| Autor: | Lucia Salvatorelli, Gaetano Magro, Francesca Catalano, Fabio Motta, Saveria Spadola, Juan P. Palazzo, Giada Maria Vecchio |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Solitary fibrous tumor Pathology medicine.medical_specialty Metaplastic carcinoma CD34 Breast Neoplasms Nodular fasciitis STAT 6 Pathology and Forensic Medicine Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Diagnosis medicine Dermatofibrosarcoma protuberans Biomarkers Tumor Spindle cell lesions Humans Breast Key words Immunohistochemistry Aged Female Middle Aged STAT6 Transcription Factor Solitary Fibrous Tumors 2734 Cell Biology Tumor business.industry Fibromatosis medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Spindle cell lipoma Differential business Myofibroblastoma Biomarkers |
| Popis: | The diagnosis of spindle cell lesions of the breast parenchyma is challenging. Some of these lesions share the expression of CD34, posing differential diagnostic problems, especially in core biopsies. Recently, antibodies against the STAT6 C-terminal, are being used in paraffin-embedded tissues as a surrogate for identifying the NAB2-STA6 fusion gene which is considered a specific molecular marker for solitary fibrous tumor. Accordingly, we investigated the expression of STAT6 in a large series of uncommon spindle cell tumor-like and tumor lesions occurring primarily in the breast parenchyma. We collected 10 classic-type myofibroblastomas, 9 desmoid-type fibromatosis, 6 spindle cell metaplastic carcinoma, 5 benign fibroblastic spindle cell tumors, 3 solitary fibrous tumors, 7 pseudoangiomatous stromal hyperplasias, 2 reactive spindle cell nodules, 1 leiomyoma, 1 spindle cell lipoma, 1 case of inflammatory pseudotumor, 1 nodular fasciitis, 1 myxoma and 1 dermatofibrosarcoma protuberans. A diffuse and strong nuclear STAT6 expression was restricted only to solitary fibrous tumors, while the other lesions were negative or showed only weak cytoplasmic expression. The present study confirms that the demonstration of a diffuse and strong STAT6 nuclear staining is very helpful in distinguishing solitary fibrous tumor from other spindle cell mimics arising in the breast. |
| Databáze: | OpenAIRE |
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