Leaf extract of Alpinia purpurata (Vieill.) K. Schum screened for its phytochemical constituents and antibacterial and anticancer activities
| Autor: | Rathi Ma, Dominic Sophia, Paramasivam Ragavendran, Thangarajan Starlin, Velliyur Kanniappan Gopalakrishnan, Arul Raj C |
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| Rok vydání: | 2012 |
| Předmět: |
Solvent system
Traditional medicine biology Plant Extracts Ovarian cancer cell line Ethyl acetate biology.organism_classification Antineoplastic Agents Phytogenic Anti-Bacterial Agents Plant Leaves chemistry.chemical_compound Complementary and alternative medicine Phytochemical chemistry Cell Line Tumor Alpinia purpurata Alpinia Humans Agar diffusion test Antibacterial activity |
| Zdroj: | Journal of Chinese Integrative Medicine. 10:1460-1464 |
| ISSN: | 1672-1977 |
| DOI: | 10.3736/jcim20121219 |
| Popis: | Objective The study was formulated with the objective to assess phytochemical constituents, antibacterial activity and anticancer activity of Alpinia purpurata. Methods The leaves of A. purpurata were washed thoroughly by tap water, shade dried and powdered. The plant powder was extracted with successive solvent system. Phytochemical constituents were evaluated, antibacterial activity was carried out by disc diffusion method and anticancer activity of the ethyl acetate leaf extract was evaluated by using 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Results The ethyl acetate extract of A. purpurata showed most of the phytochemicals. The extract exhibited antibacterial activity with a zone of inhibition from 5 to 14 mm at various concentrations and the extract showed potential anticancer activity against PA1 ovarian cancer cell line at the 48 h with half maximal inhibitory concentration value of 110.25 μg/mL and exhibited a dose-dependent decrease in cell count for all the concentrations tested. Conclusion The present study scientifically proved that ethyl acetate leaf extract of A. purpurata is a good source of phytoconstituents, showing antibacterial and anticancer activities. |
| Databáze: | OpenAIRE |
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