Elevated serum levels of neutrophil elastase in patients with influenza virus-associated encephalopathy
| Autor: | Naomi Hino-Fukuyo, Mitsugu Uematsu, Shigeo Kure, Taro Kitamura, Masaru Takayanagi, Mitsutoshi Munakata, Hitoshi Mikami, Chiharu Ota, Kazuhiro Haginoya, Yoko Chiba, Hiromi Fujie, Setsuko Kitaoka, Guilian Sun, Katsuya Yamamoto |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Male
Chemokine medicine.medical_treatment Interleukin-1beta Encephalopathy Virus Granulocyte Colony-Stimulating Factor Influenza Human E-selectin medicine Humans In patient Encephalitis Viral Child Interleukin-13 Tissue Inhibitor of Metalloproteinase-1 biology Interleukin-6 Tumor Necrosis Factor-alpha Cell adhesion molecule business.industry Interleukin-7 Interleukin-8 Granulocyte-Macrophage Colony-Stimulating Factor Infant medicine.disease Interleukin-10 Cytokine Neurology Child Preschool Neutrophil elastase Immunology biology.protein Cytokines Interleukin-2 Female Neurology (clinical) Interleukin-5 E-Selectin Leukocyte Elastase business |
| Zdroj: | Journal of the Neurological Sciences. 349:190-195 |
| ISSN: | 0022-510X |
| Popis: | We examined serum levels of various cytokines, chemokines, growth factors, and adhesion molecules in patients with uncomplicated influenza (n = 20) and influenza virus-associated encephalopathy (IE) (n = 18) to understand the underlying mechanism of IE. We found that IL-1β, IL-2, IL-5, IL-6, IL-7, IL-8, IL-10, IL-13, G-CSF, GM-CSF, TNF-α, TIMP-1, MMP-9, sE-selectin, and neutrophil elastase were elevated significantly in sera from patients with uncomplicated influenza and those with IE, compared with normal controls (n = 20). Of note, neutrophil elastase, sE-selectin, IL-8, and IL-13 were elevated significantly in IE as compared with uncomplicated influenza. In the present study, for the first time, we found that serum levels of neutrophil elastase were increased in patients with IE compared with uncomplicated influenza, which suggested that cerebral endothelial damage in the development of IE was mediated by neutrophil elastase. The present study implied that anti-elastase agents are possibly an effective therapeutic protocol for IE, but this needs further elucidation. |
| Databáze: | OpenAIRE |
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