Cardioprotective Effect of Selective Estrogen Receptor Modulator Raloxifene Are Mediated by Heme Oxygenase in Estrogen-Deficient Rat

Autor: Krisztina Kupai, Mariann Gyöngyösi, Anikó Pósa, Renáta Szabó, Médea Veszelka, Anikó Magyariné Berkó, Denise Börzsei, Gergő Szűcs, Zoltán Szilvássy, Zoltán Deim, Imre Pavo, Csaba Varga, Bela Juhasz
Rok vydání: 2017
Předmět:
0301 basic medicine
Aging
medicine.medical_specialty
Vasopressin
Cardiotonic Agents
animal structures
Article Subject
Arginine
medicine.drug_class
Ovariectomy
Myocardial Ischemia
030204 cardiovascular system & hematology
Biochemistry
Gene Expression Regulation
Enzymologic
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Animals
Raloxifene
Elméleti orvostudományok
Rats
Wistar
lcsh:QH573-671
biology
lcsh:Cytology
Chemistry
Raloxifene Hydrochloride
Estrogens
Orvostudományok
Cell Biology
General Medicine
Rats
Heme oxygenase
030104 developmental biology
Endocrinology
Receptors
Estrogen
Estrogen
Selective estrogen receptor modulator
Myeloperoxidase
Heme Oxygenase (Decyclizing)
biology.protein
Female
hormones
hormone substitutes
and hormone antagonists
Research Article
medicine.drug
Zdroj: Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)
Oxidative Medicine and Cellular Longevity
ISSN: 1942-0994
1942-0900
Popis: Estrogens and raloxifene (RAL) have beneficial effects on certain cardiovascular indices in postmenopausal women characterized by estrogen deficiency. Heme oxygenase (HO) activity is increased by 17β-estradiol (E2) and RAL in estrogen-deficient rat resulting in vasorelaxation mediated by carbon monoxide. We determined the expressions of HO in cardiac and aortic tissues after ovariectomy (OVX) and subsequent RAL or E2treatment. We investigated the effects of pharmacological inhibition of HO enzyme on the arginine vasopressin- (AVP-) induced blood pressure in vivo, the epinephrine- and phentolamine-induced electrocardiogram ST segment changes in vivo, and the myeloperoxidase (MPO) enzyme activity. When compared with intact females, OVX decreased the HO-1 and HO-2 expression, aggravated the electrocardiogram signs of heart ischemia and the blood pressure response to AVP, and increased the cardiac MPO. E2and RAL are largely protected against these negative impacts induced by OVX. The pharmacological inhibition of HO in E2- or RAL-treated OVX animals, however, restored the cardiovascular status close to that observed in nontreated OVX animals. The decreased expression of HO enzymes and the changes in blood pressure ischemia susceptibility and inflammatory state in OVX rat can be reverted by the administration of E2or RAL partly through its antioxidant and anti-inflammatory roles.
Databáze: OpenAIRE
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