Axillary metastases in breast cancer patients with negative sentinel nodes: A follow-up of 3548 cases
| Autor: | Giuseppe Viale, Nicole Rotmensz, Giovanni Paganelli, Patrick Maisonneuve, Mattia Intra, Pietro Caldarella, Luciana N. De Brito Lima, Paolo Veronesi, Roberto Orecchia, Stefano Zurrida, Viviana Galimberti, Alberto Luini, Claudia Sangalli, Giuseppe Renne, Marco Tullii, Umberto Veronesi |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Reoperation Risk medicine.medical_specialty Cancer Research Breast Neoplasms Kaplan-Meier Estimate Premises Overt axillary metastases Metastasis NO Breast cancer medicine Carcinoma Negative sentinel node biopsy Oncology Humans Survival rate Aged Proportional Hazards Models Sentinel Lymph Node Biopsy business.industry Carcinoma Ductal Breast Middle Aged Sentinel node medicine.disease Combined Modality Therapy Surgery Survival Rate Axilla Treatment Outcome medicine.anatomical_structure Receptors Estrogen Lymphatic Metastasis Female Breast disease business Follow-Up Studies |
| Popis: | Premises Sentinel node biopsy (SNB) in patients with breast carcinoma accurately predicts the axillary node status. However, in some 4–7% of patients with negative sentinel nodes, the remaining axillary nodes harbour cancer cells. Objective Our purpose was the long-term observation of a large number of patients who did not receive axillary dissection after a negative sentinel node biopsy, in order to evaluate the incidence of overt axillary metastases. Methods Patients (3548) treated from 1996 to 2004, with negative sentinel nodes not submitted to axillary dissection, were followed up to 11 years with a median follow-up of 48 months. Results Three hundred and sixteen unfavourable events occurred among the 3548 patients, 196 of which (5.5%) related to primary breast carcinoma. Thirty one cases of overt axillary metastases were found (0.9%): they received total axillary dissection and 27 of them are at present alive and well. The 5-year overall survival rate of the whole series was 98%. Conclusions Patients with negative sentinel node biopsy not submitted to axillary dissection show, at follow-up, a rate of overt axillary metastases lower than expected. |
| Databáze: | OpenAIRE |
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