Cohort Profile: The Cohorts Consortium of Latin America and the Caribbean (CC-LAC)
Autor: | Leila Beltrami Moreira, Betty S Manrique-Espinoza, Elard Koch, Dalia Stern, Catterina Ferreccio, Claudia Bambs, Adrian Cortes-Valencia, Ione Jayce Ceola Schneider, Marselle B Amadio, José Geraldo Mill, José Boggia, Gilbert Brenes-Camacho, Lariane M Ono, Alvaro Cc Maciel, Walter G Espeche, Poli Mara Spritzer, Fernando Luiz Herkenhoff, J. Jaime Miranda, Adolfo Rubinstein, Horacio A Carbajal, Cecilia Baccino, Andrea R. V. R. Horimoto, Anselm Hennis, Gonzalo Grazioli, Mariachiara Di Cesare, Katia Vergetti Bloch, Ricardo Oliveira Guerra, Gloria L. Beckles, João Luiz Bastos, Álvaro Ruiz-Morales, Alexandre C. Pereira, Ramon A Sanchez, Fiorella Tartaglione, Antonio Bernabe-Ortiz, Roberto de Sa Cunha, Luis Rosero-Bixby, Vilma Irazola, Rodrigo M. Carrillo-Larco, Martin R Salazar, Thiago L N Silva, Pollyanna Kássia de Oliveira Borges, Ian Hambleton, Juan E. Blümel, Flávio Danni Fuchs, Aaron Salinas-Rodriguez, Ramón Álvarez-Vaz, Eleonora d'Orsi, David Alejandro González-Chica, Paulo A. Lotufo, Sérgio Viana Peixoto, Sandra Cortés, Goodarz Danaei, Rosalba Rojas-Martínez, Suely Godoy Agostinho Gimeno, Karen Glazer Peres, Jackie A. Cooper, Maria Fernanda Lima-Costa, Larissa Pruner Marques, Marco Aurélio Peres, Nohora I Rodriguez, William H. Dow, Edward W. Gregg, Laura Gutierrez, Clicerio González-Villalpando, Liam Smeeth, Jorge Tartaglione, Miguel Bravo, Oscar Muñoz, Maria S. Castillo Rascon, Karen Oppermann, María-Elena González-Villalpando, Blanca H. Ceballos, Susana Cararo Confortin, Ruy Lopez-Ridaura, Majid Ezzati, Andrea Huidobro, Carlos A. Aguilar-Salinas, Verônica Colpani, Sandra C. Fuchs, Nelson A S Silva, Donaji Gomez-Velasco, Pablo Perel, Martin Lajous, Carla de Oliveira Bernardo |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Framingham Risk Score Latin Americans Epidemiology business.industry General Medicine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Health care Cohort Global health Medicine AcademicSubjects/MED00860 030212 general & internal medicine business Cohort Profiles Disease burden Demography Cohort study |
Zdroj: | International Journal of Epidemiology |
ISSN: | 1464-3685 0300-5771 |
DOI: | 10.1093/ije/dyaa073 |
Popis: | Why was the cohort set up? Latin America and the Caribbean (LAC) are characterized by much diversity in terms of socio-economic status, ecology, environment, access to health care,1,2 as well as the frequency of risk factors for and prevalence or incidence of non-communicable diseases;3–7 importantly, these differences are observed both between and within countries in LAC.8,9 LAC countries share a large burden of non-communicable (e.g. diabetes and hypertension) and cardiovascular (e.g. ischaemic heart disease) diseases, with these conditions standing as the leading causes of morbidity, disability and mortality in most of LAC.10–12 These epidemiological estimates—e.g. morbidity—cannot inform about risk factors or risk prediction, which are relevant to identify prevention avenues. Cohort studies, on the other hand, could provide this evidence. Pooled analysis, using data from multiple cohort studies, have additional strengths such as increased statistical power and decreased statistical uncertainty.13 LAC cohort studies have been under-represented,14 or not included at all,15–17 in international efforts aimed at pooling data from multiple cohort studies. We therefore set out to pool data from LAC cohorts to address research questions that individual cohort studies would not be able to answer. Drawing from previous successful regional enterprises (e.g. Asia Pacific Cohort Studies Collaboration),18,19 we established the Cohorts Consortium of Latin America and the Caribbean (CC-LAC). The main aim of the CC-LAC is to start a collaborative cohort data pooling in LAC to examine the association between cardio-metabolic risk factors (e.g. blood pressure, glucose and lipids) and non-fatal and fatal cardiovascular outcomes (e.g. stroke or myocardial infarction). In so doing, we aim to provide regional risk estimates to inform disease burden metrics, as well as other ambitious projects including a cardiovascular risk score to strengthen cardiovascular prevention in LAC. Initial funding has been provided by a fellowship from the Wellcome Trust Centre for Global Health Research at Imperial College London (Strategic Award, Wellcome Trust–Imperial College Centre for Global Health Research, 100693/Z/12/Z). Additional funding is being provided by an International Training Fellowship from the Wellcome Trust (214185/Z/18/Z). At the time of writing, the daily operations and pooled database are hosted at Imperial College London, though a mid-term goal is to transfer this expertise and operations to LAC. The collaboration relies fundamentally on a strong regional network of health researchers and practitioners |
Databáze: | OpenAIRE |
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