Tracking Inhibitory Control in Youth With ADHD: A Multi-Modal Neuroimaging Approach
Autor: | Lescia K Tremblay, Jason P. Lerch, Donald J. Mabbott, Stephanie H. Ameis, Russell Schachar, Christopher Hammill, Evdokia Anagnostou, Mehereen Bhaijiwala |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
lcsh:RC435-571 attention deficit hyperactivity disorder (ADHD) stop signal task Stop signal Audiology behavioral disciplines and activities White matter 03 medical and health sciences 0302 clinical medicine diffusion tensor imaging (DTI) tractography lcsh:Psychiatry Fractional anisotropy Medicine Cingulum (brain) Attention deficit hyperactivity disorder Cognitive deficit Original Research Psychiatry youth business.industry medicine.disease 030227 psychiatry inhibitory control Psychiatry and Mental health medicine.anatomical_structure Endophenotype Posterior cingulate medicine.symptom business 030217 neurology & neurosurgery |
Zdroj: | Frontiers in Psychiatry Frontiers in Psychiatry, Vol 11 (2020) |
ISSN: | 1664-0640 |
Popis: | Background A decreased ability to inhibit a speeded motor response is a well-studied deficit in Attention Deficit Hyperactivity Disorder (ADHD), and has been proposed as an endophenotype. Inhibitory control has been assessed reliably with the Stop Signal Task (SST) and is associated with prior documented differences in regional brain function using f-MRI. Here, we advance on these findings by examining their structural connectivity and white matter integrity with the goal of identifying a network underlying a core cognitive deficit in ADHD. Methods Healthy controls (N=16) and youth diagnosed with ADHD (N=60) were recruited through the Province of Ontario Neurodevelopmental Disorders Network (POND) and the Hospital for Sick Children. An f-MRI activation difference map was co-registered with each participant's white matter imaging data, representing the specific network nodes where ADHD youth diverged significantly from controls while performing the SST. Probabilistic tractography was applied from these nodes, and white matter integrity indices such as fractional anisotropy (FA) within the tracts of interest were contrasted between the groups and correlated with SST output measures, including the measure of inhibitory control, the stop signal reaction time (SSRT). Results The tracts that connected the network nodes belonged primarily to the inferior fronto-occipital fasciculus (IFOF) and cingulum. ADHD subjects showed trend differences in FA compared to controls between right inferior frontal gyrus (IFG) and right superior temporal gyrus (P= 0.09), right IFG and right posterior cingulate (P= 0.01), right anterior cingulate to posterior cingulate (p= 0.08), and between left middle temporal gyrus (BA 39) and left posterior cingulate (P=0.02). A trend correlation was found between radial diffusivity within IFG to STG white matter (IFOF) and SSRT. Conclusions We identified potential white matter tracts related to deficient inhibitory control, elucidating the brain mechanisms of an important cognitive deficit in ADHD. These findings could be integrated into future endophenotypic biomarker studies, incorporating altogether brain structure, function, and behavior for future studies of ADHD and other psychiatric conditions that exhibit this deficit. |
Databáze: | OpenAIRE |
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