Exposure to an enriched environment up to middle age allows preservation of spatial memory capabilities in old age
| Autor: | Fanny Fuchs, Chantal Mathis, Lorène Penazzi, Alexandra Barbelivien, Monique Majchrzak, Christian Kelche, Brigitte Cosquer |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Aging Environmental enrichment Cognition Water maze Environment Middle age Rats Developmental psychology Disease Models Animal 03 medical and health sciences Behavioral Neuroscience Adult life 030104 developmental biology 0302 clinical medicine Spatial learning Animals Female Young adult Maze Learning Psychology 030217 neurology & neurosurgery Spatial Memory Cognitive reserve Demography |
| Zdroj: | Behavioural Brain Research. 299:1-5 |
| ISSN: | 0166-4328 |
| Popis: | In rats, some cognitive capabilities, like spatial learning and memory, are preserved from age-related decline by whole adult life enriched environment (EE) exposure. However, to which extent late EE contributes to such maintenance remains to be investigated. Here we assessed the impact of late housing condition (e.g., from the age of 18 months) on spatial learning and memory of aged rats (24 months) previously exposed or unexposed to EE from young adulthood. The results showed that late EE was not required for spatial memory maintenance in aged rats previously housed in EE. In contrast, late EE mitigates spatial memory deficit in aged rats previously unexposed to EE. These outcomes suggest that EE exposure up to middle age provides a "reserve"-like advantage which supports an enduring preservation of spatial capabilities in old age. |
| Databáze: | OpenAIRE |
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