Use of ultrasonic vocalizations to assess olfactory detection in mouse pups treated with 3-methylindole
| Autor: | Morgane Lemasson, Charles Delbé, Gilles Gheusi, Jean-Didier Vincent, Pierre-Marie Lledo |
|---|---|
| Přispěvatelé: | Perception et Mémoire, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] (LEAD), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Institut de Neurobiologie Alfred Fessard (INAF), Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB), Institut Pasteur [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Etude de l'Apprentissage et du Développement [Dijon] ( LEAD ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Olfactory system
Male [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology MESH: Ultrasonics MESH : Behavior Animal MESH: Animals Newborn Behavioral Neuroscience Mice 0302 clinical medicine Discrimination Psychological Ultrasound emission MESH: Smell MESH: Behavior Animal Ultrasonics MESH: Animals MESH: Discrimination (Psychology) Olfactotoxin Behavior Animal MESH : Animals Newborn 05 social sciences General Medicine MESH : Odors Skatole Smell Altricial medicine.anatomical_structure [ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] MESH : Ultrasonics MESH : Sensory Deprivation MESH : Male MESH: Vocalization Animal MESH: Skatole Sensory system MESH : Mice Inbred C57BL Olfaction Biology Development 03 medical and health sciences MESH: Mice Inbred C57BL MESH : Mice medicine Animals 0501 psychology and cognitive sciences Sensory deprivation 050102 behavioral science & comparative psychology MESH: Mice Behavior MESH: Sensory Deprivation MESH: Odors MESH : Vocalization Animal MESH : Skatole MESH : Discrimination (Psychology) MESH: Male Olfactory bulb Mice Inbred C57BL Odor Animals Newborn Odorants MESH : Smell Animal Science and Zoology MESH : Animals Sensory Deprivation Vocalization Animal Olfactory epithelium Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Behavioural Processes Behavioural Processes, Elsevier, 2005, 68 (1), pp.13-23. ⟨10.1016/j.beproc.2004.09.001⟩ Behav Processes Behav Processes, 2005, 68 (1), pp.13-23. ⟨10.1016/j.beproc.2004.09.001⟩ Behavioural Processes, Elsevier, 2005, 68 (1), pp.13-23. 〈10.1016/j.beproc.2004.09.001〉 Behavioural Processes, 2005, 68 (1), pp.13-23. ⟨10.1016/j.beproc.2004.09.001⟩ |
| ISSN: | 0376-6357 1872-8308 |
| DOI: | 10.1016/j.beproc.2004.09.001⟩ |
| Popis: | International audience; Altricial mammals use olfaction long before the olfactory bulb has reached its anatomically mature state. Indeed, while audition and vision are still not functional, the olfactory system of newborn animals can clearly process distinct odorant molecules. Although several previous studies have emphasized the important role that olfaction plays in early critical functions, it has been difficult to develop a sensitive and reliable test to precisely quantify olfactory ability in pups. One difficulty in determining early sensory capabilities is the rather limited behavioral repertory of neonates. The present study examines the use of ultrasonic vocalizations emitted by isolated rodent pups as a potential index of odor detection in newborn mice. As early as postnatal day 2, mice reliably decrease their emission of ultrasonic calls in response to odor exposure to the bedding of adult male mice but not in response to clean bedding odors or to non-social odorant molecules. A toxin known to damage the olfactory epithelium in adult, the 3-methylindole, impairs the ultrasonic call responses triggered by exposure to male bedding, thus confirming the efficiency of this olfactotoxin on mice pups. The administration of 3-methylindole severely reduced the life expectancy of the majority of subjects. This result is discussed according to the critical role of olfaction in nipple-seeking behavior in mouse pups. |
| Databáze: | OpenAIRE |
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