Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule
| Autor: | Shireen A. Davies, Pablo Cabrero, Selim Terhzaz, Guillermo Martínez-Corrales, Julian A. T. Dow |
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| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Malpighian tubule system biology Cell growth biology.organism_classification 3. Good health Cell biology 03 medical and health sciences 0302 clinical medicine Tubule Hepatic stellate cell Stem cell Drosophila melanogaster Molecular Biology Transcription factor 030217 neurology & neurosurgery Renal stem cell 030304 developmental biology Developmental Biology |
| Zdroj: | Development |
| ISSN: | 1477-9129 0950-1991 |
| Popis: | The GATA family of transcription factors is implicated in numerous developmental and physiological processes in metazoans. In Drosophila melanogaster, 5 different GATA factors (pannier, serpent, grain, GATAd and GATAe) have been reported as essential in the development and identity of multiple tissues, including the midgut, heart and brain. Here, we present a novel role of GATAe in the function and homeostasis of the Drosophila renal (Malpighian) tubule. We demonstrate that reduced levels of GATAe gene expression in tubule principal cells induce uncontroled cell proliferation, resulting in tumorous growth with associated altered expression of apoptotic and carcinogenic key genes. Further, we uncover an involvement of GATAe in the maintenance of stellate cells and migration of renal and nephritic stem cells into the tubule. Our findings of GATAe as a potential master regulator in the events of growth control and cell survival required for the maintenance of the Drosophila renal tubule could provide new insights into the molecular pathways involved in the formation and maintenance of a functional tissue and kidney disease. |
| Databáze: | OpenAIRE |
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