Neuroprotective effects of Buchholzia coriacea seed extract on sodium azide-induced neurotoxicity of the prefrontal cortex of Wistar rats
| Autor: | O David, B.J. Dare, O.O. Obembe, T.A. Abayomi, O.S. Tokunbo |
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| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
Chemistry Neurotoxicity 030206 dentistry Glutathione Pharmacology medicine.disease_cause medicine.disease Neuroprotection 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Buchholzia coriacea Sodium Azide Neurodegeration Prefrontal cortex medicine Sodium azide Neurotoxin Buchholzia coriacea Pediatrics Perinatology and Child Health Prefrontal cortex 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Anatomy Journal of Africa; Vol 8, No 2 (2019); 1635-1646 |
| ISSN: | 2305-9478 2226-6054 |
| Popis: | This study was designed to evaluate the therapeutic potentials and neuroprotective effects of methanol extract of Buchholzia coriacea (BC) seeds on sodium azide (NaN 3 ) induced neurotoxicity of the prefrontal cortex in male Wistar rats. Neurotoxicity occurs as a result of exposure to neurotoxins in the environment, of which NaN 3 is a potent neurotoxin. Thirty male Wistar rats were were randomly divided into 5 groups. Group A were administered with distilled water. Group B was administered with NaN 3 for 28 days. Group C was administered with NaN 3 for 28 days and thereafter B. coriacea for 21 days. Group D was administered with B. coriacea for 21 days and then NaN 3 for 28 days. Group E was administered with only B. coriacea for 21 days. After treatment, neurobehavioral assessment was carried out after which the rats were sacrificed, and the prefrontal cortex excised. The prefrontal cortex was then processed for histological and biochemical analysis (SOD, MDA, GSH, and CAT). Pre-treatment and post-treatment with Buchholzia coriacea revitalized the cells of the Prefrontal cortex which were damaged by NaN 3 exposure. Oxidative stress levels also decreased as a result of B. coriacea treatment, suggesting neuroprotective effects of Buchholzia Coriacea . Keywords: Buchholzia coriacea , Sodium Azide, Neurodegeration, Prefrontal cortex |
| Databáze: | OpenAIRE |
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