Liver Stiffness Measurement in Psoriasis: Do Metabolic or Disease Factors Play the Important Role?
| Autor: | Supanna Petraksa, Ammarin Thakkinstian, Piyaporn Kaewduang, Wasana Stitchantrakul, Chomsri Kositchaiwat, Saneerat Porntharukchareon, Natta Rajatanavin, Abhasnee Sobhonslidsuk, Kwannapa Promson, Jamrus Pongpit |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Pathology Waist Article Subject lcsh:Medicine Gastroenterology General Biochemistry Genetics and Molecular Biology 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Fibrosis Non-alcoholic Fatty Liver Disease Internal medicine Diabetes mellitus Psoriasis Nonalcoholic fatty liver disease Prevalence Medicine Humans Metabolic Syndrome General Immunology and Microbiology business.industry Cumulative dose lcsh:R General Medicine Middle Aged medicine.disease Liver Elasticity Imaging Techniques 030211 gastroenterology & hepatology Female Metabolic syndrome business Transient elastography Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2016 (2016) |
| ISSN: | 2314-6133 |
| DOI: | 10.1155/2016/7963972 |
| Popis: | Background. An increased prevalence of metabolic syndrome including nonalcoholic fatty liver disease (NAFLD) was reported in psoriasis. NAFLD can progress to nonalcoholic steatohepatitis and fibrosis. Transient elastography (TE) is a noninvasive liver fibrosis assessment. We evaluated the prevalence of significant liver fibrosis or high liver stiffness measurement (LSM) using the LSM cutoff over 7 kPa and its associated factors in psoriatic patients. Methods. Subjects underwent TE and ultrasonography. Univariate and multivariate analysis were performed for the associated factors. Results. One hundred and sixty-eight patients were recruited. Three patients were excluded due to TE failure. Mean BMI was 24.8±4.7 kg/m2. NAFLD, metabolic syndrome, and diabetes were seen in 105 (63.6%), 83 (50.3%), and 31 (18.8%) patients. The total cumulative dose of methotrexate over 1.5 g was seen in 39 (23.6%) patients. Mean LSM was 5.3±2.9 kPa. High LSM was found in 18 (11.0%) patients. Waist circumference (OR: 1.24; 95% CI: 1.11–1.38; P=0.0002), diabetes (OR: 12.70; 95% CI: 1.84–87.70; P=0.010), and AST (OR: 1.08; 95% CI: 1.02–1.16; P=0.017) were associated with high LSM. Conclusion. 11% of psoriatic patients had significant liver fibrosis by high LSM. Waist circumference, diabetes, and AST level were the independent predictors. |
| Databáze: | OpenAIRE |
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