Distinct Footprints of TCR Engagement with Highly Homologous Ligands
| Autor: | David A. Ostrov, Kaisa Holmberg, Stanislav Vukmanovic, Nicholas R. J. Gascoigne, Fabio R. Santori |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Models
Molecular T cell CD3 Immunology Receptors Antigen T-Cell Epitopes T-Lymphocyte Mice Transgenic chemical and pharmacologic phenomena Peptide Biology Ligands Major histocompatibility complex Mice Structure-Activity Relationship T-Lymphocyte Subsets Homologous chromosome medicine Animals Immunology and Allergy Avidity Amino Acid Sequence Protein Footprinting Genetics chemistry.chemical_classification Antigen Presentation Ligand T-cell receptor hemic and immune systems Cell biology medicine.anatomical_structure chemistry biology.protein Peptides Epitope Mapping Protein Binding |
| Zdroj: | The Journal of Immunology. 172:7466-7475 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.172.12.7466 |
| Popis: | T cell receptor engagement promotes proliferation, differentiation, survival, or death of T lymphocytes. The affinity/avidity of the TCR ligand and the maturational stage of the T cell are thought to be principal determinants of the outcome of TCR engagement. We demonstrate in this study that the same mouse TCR preferentially uses distinct residues of homologous peptides presented by the MHC molecules to promote specific cellular responses. The preference for distinct TCR contacts depends on neither the affinity/avidity of TCR engagement (except in the most extreme ranges), nor the maturity of engaged T cells. Thus, different portions of the TCR ligand appear capable of biasing T cells toward specific biological responses. These findings explain differences in functional versatility of TCR ligands, as well as anomalies in the relationship between affinity/avidity of the TCR for the peptide/MHC and cellular responses of T cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|