Prevalence and characteristics of serrated lesions of the colorectum in Italy: A multicentre prospective cohort study
| Autor: | Gianluca Rotondano, Maria Antonia Bianco, Livio Cipolletta, Riccardo Marmo, Federico Buffoli, Teresa Staiano, Stefano Sansone, Giuseppe Spinosa, Giovanni De Maio, Luciano Corazza, Giuseppe Gizzi, Francesco Munizzi, Guido Costamagna, Lucio Petruzziello, Antonio Spadaccini, Michele Silla, Marco Silvestrelli |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adenoma
Adult Male medicine.medical_specialty Cross-sectional study Colorectal cancer Settore MED/18 - CHIRURGIA GENERALE Colonoscopy Rectum Gastroenterology Internal medicine medicine Prevalence Humans Serrated adenoma Prospective Studies Prospective cohort study Aged Hepatology medicine.diagnostic_test business.industry Incidence (epidemiology) Serrated polyp Intestinal Polyps Middle Aged medicine.disease digestive system diseases medicine.anatomical_structure Cross-Sectional Studies Hyperplastic Polyp Italy Risk factors Female business Colorectal Neoplasms Precancerous Conditions |
| Popis: | Serrated lesions are recognized as important contributors to colorectal cancer incidence. We aimed to prospectively assess the prevalence of serrated lesions and identify potential predictors of these lesions during colonoscopy in an Italian population.Prospective cross sectional study involving 8 endoscopy units from February 1st to July 31st 2012.Out of 2468 colonoscopies, 886 precancerous lesions were detected in 567 patients. Of these, 173 SELs were diagnosed in 148 patients (140 serrated/hyperplastic polyps and 33 serrated adenomas). Prevalence was 7% (173/2468). Serrated lesions accounted for 19.5% of all precancerous lesions. Serrated polyps were prevalent in the left colon (42.1%) and serrated adenomas in the proximal colon (54.5%). Independent clinical predictors of serrated lesions were patient age (OR 0.98 [0.97-1.00]) and post-polypectomy surveillance (OR 1.87 [1.24-2.82]). Endoscopic predictors were right colon location (OR 2.65 [1.63-4.30] vs. rectum; and 1.53 [1.03-2.26] vs. left colon), polypoid shape (OR 0.41 [027-0.64]) and size6 mm (OR 0.49 [0.33-0.72] vs. 6-10 mm; and 0.14 [0.07-0.28] vs.10 mm). There was no independent predictor of serrated adenoma.In our Italian study population, the prevalence of colorectal serrated lesions was 7%. Their diagnosis is associated with younger age and surveillance colonoscopy, right-sided colorectal location, non-polypoid shape and size6 mm. |
| Databáze: | OpenAIRE |
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