Glycerol catabolism in Aspergillus nidulans
| Autor: | D.H.A. Hondmann, C.F.B. Witteveen, R. Busink, Jantien Visser |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Glycerol
Glycerol kinase Catabolite repression Dihydroxyacetone Glycerolphosphate Dehydrogenase Dehydrogenase Laboratorium voor Erfelijkheidsleer Microbiology Aspergillus nidulans chemistry.chemical_compound Glycerol Kinase Life Science Alcohol dehydrogenase biology Alcohol Dehydrogenase biology.organism_classification Carbon Mitochondria Biochemistry chemistry Mutation biology.protein Glycerol dehydrogenase Laboratory of Genetics |
| Zdroj: | Journal of general microbiology 137 (1991) Journal of general microbiology, 137, 629-636 |
| ISSN: | 0022-1287 |
| DOI: | 10.1099/00221287-137-3-629 |
| Popis: | Glycerol is catabolized in Aspergillus nidulans by glycerol kinase and a mitochondrial FAD-dependent sn-glycerol 3-phosphate dehydrogenase. The levels of both enzymes are controlled by carbon catabolite repression and by specific induction. Biochemical and genetical analyses show that dihydroxyacetone and D-glyceraldehyde are converted into glycerol and then catabolized by the same pathway. D-Glyceraldehyde can be reduced by NADP(+)-dependent glycerol dehydrogenase or by alcohol dehydrogenase I, while dihydroxyacetone is only reduced by the first enzyme. Three new glycerol non-utilizing mutants have been found. These three mutations define three hitherto unknown loci, glcE, glcF and glcG. The mutation in glcG leads to a greatly decreased sn-glycerol-3-phosphate dehydrogenase activity. |
| Databáze: | OpenAIRE |
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