Development of tetrahydrobiopterin and GTP cyclohydrolase in salivary glands of rats
| Autor: | Katoh Setsuko, Sueoka Terumi |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Aging GTP' Tyrosine 3-Monooxygenase Adrenergic Biology Biochemistry Salivary Glands chemistry.chemical_compound Biosynthesis Aminohydrolases Internal medicine medicine Animals Adult stage GTP Cyclohydrolase chemistry.chemical_classification Tyrosine hydroxylase Pteridines Rats Inbred Strains Tetrahydrobiopterin Biopterin Rats Kinetics Enzyme Endocrinology chemistry Catecholamine medicine.drug |
| Zdroj: | The International journal of biochemistry. 18(2) |
| ISSN: | 0020-711X |
| Popis: | 1. 1. A significant amount of 5,6,7,8-tetrahydrobiopterin (BH4), an essential cofactor of tyrosine hydroxylase, and the activity of GTP cyelohydrolase (GTP cycl), the first and rate-limiting enzyme in BH4 biosynthesis, were found in rat salivary glands, in which adrenergic transmitters are localized, from day 4 through 56 after birth. 2. 2. About 90 ng of BH4 per g wet weight were determined in the glands (submandibular and sublingual) of adult rats. 3. 3. The levels of them which were maintained from 2 weeks after birth up to the adult stage correlated with a previous finding in the maintenance of catecholamine concentration during the same stage in rat salivary glands. |
| Databáze: | OpenAIRE |
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