Amyloid‐dependent and amyloid‐independent effects of Tau in individuals without dementia
| Autor: | Pamela C.L. Ferreira, Sulantha Mathotaarachchi, Marcus Sefranek, Joseph Therriault, Serge Gauthier, Firoza Z. Lussier, Pedro Rosa-Neto, Tharick A. Pascoal, Paramita Saha-Chaudhuri, Cecile Tissot, Mira Chamoun, Andrea Lessa Benedet, Eduardo R. Zimmer, Bruna Bellaver |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Male medicine.medical_specialty Amyloid Clinical Dementia Rating Neurosciences. Biological psychiatry. Neuropsychiatry Standardized uptake value Neocortex tau Proteins Cohort Studies Internal medicine mental disorders medicine Dementia Humans Cognitive Dysfunction RC346-429 Research Articles Aged Aged 80 and over Amyloid beta-Peptides business.industry General Neuroscience Cognition Middle Aged medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Posterior cingulate Positron-Emission Tomography Cohort Female Neurology. Diseases of the nervous system Neurology (clinical) Amnesia business RC321-571 Research Article |
| Zdroj: | Annals of Clinical and Translational Neurology Annals of Clinical and Translational Neurology, Vol 8, Iss 10, Pp 2083-2092 (2021) |
| ISSN: | 2328-9503 |
| Popis: | Objective To investigate the relationship between the topography of amyloid‐β plaques, tau neurofibrillary tangles, and the overlap between the two, with cognitive dysfunction in individuals without dementia. Methods We evaluated 154 individuals who were assessed with amyloid‐β PET with [18F]AZD4694, tau‐PET with [18F]MK6240, structural MRI, and neuropsychological testing. We also evaluated an independent cohort of 240 individuals who were assessed with amyloid‐β PET with [18F]Florbetapir, tau‐PET with [18F]Flortaucipir, structural MRI, and neuropsychological testing. Using the VoxelStats toolbox, we conducted voxel‐wise linear regressions between amyloid‐PET, tau‐PET, and their interaction with cognitive function, correcting for age, sex, and years of education. Results In both cohorts, we observed that tau‐PET standardized uptake value ratio in medial temporal lobes was associated with clinical dementia rating Sum of Boxes (CDR‐SoB) scores independently of local amyloid‐PET uptake (FWE corrected at p |
| Databáze: | OpenAIRE |
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