NEURONAL DEGENERATION, ELECTROENCEPHALOGRAPHIC DISTURBANCES AND POLYSEROSITIS IN RATS PRODUCED BY IMINODIPROPIONITRILE AND PREVENTED BY 1-THYROXINE
| Autor: | Francisco Vivanco, Carlos Jimenez Diaz, Jose A. Sanchez-Martin |
|---|---|
| Rok vydání: | 1961 |
| Předmět: |
Inflammation
Serositis medicine.medical_specialty Cyanides business.industry Electroencephalography Histopathological examination Spinal cord Rats Thyroxine Endocrinology medicine.anatomical_structure Spinal Cord Internal medicine medicine Paralysis Animals Neuronal degeneration medicine.symptom business Basophilic degeneration Paresis |
| Zdroj: | Endocrinology. 69:1111-1116 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-69-6-1111 |
| Popis: | Paresis and/or paralysis, EEC disturbances and polyserositis were observed in rats after prolonged administration of β–β′-iminodipropionitrile (IDPN). Rats treated with thyroxine simultaneously to the administration of IDPN did not show paralysis or polyserositis and the electroencephalographic pattern of this group was completely normal whereas the intoxicated animals showed electroencephalographic abnormalities. Histopathological examination of the spinal cord demonstrated that IDPN induces basophilic degeneration of the anterior motor horn cells. Thyroxine also prevents this neuronal degeneration. The practical significance of this protection is pointed out. |
| Databáze: | OpenAIRE |
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