Endometrial Cancer Associated Symptoms: A Case-Control Study
| Autor: | Diana L. Urbauer, Charlotte C. Sun, Pamela T. Soliman, J.B. Pakish, Karen H. Lu, Frances A. Smith, Anthony J. Greisinger, Bryan Fellman, Jennifer K. Burzawa |
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| Rok vydání: | 2016 |
| Předmět: |
Vaginal discharge
medicine.medical_specialty Logistic regression 03 medical and health sciences 0302 clinical medicine Surveys and Questionnaires Internal medicine medicine Humans Stage (cooking) Survival rate Early Detection of Cancer Gynecology 030219 obstetrics & reproductive medicine business.industry Endometrial cancer Case-control study Cancer Original Articles General Medicine Odds ratio Middle Aged medicine.disease Texas Endometrial Neoplasms Postmenopause Logistic Models Vaginal Discharge Case-Control Studies 030220 oncology & carcinogenesis Female Uterine Hemorrhage medicine.symptom business |
| Zdroj: | Journal of Women's Health. 25:1187-1192 |
| ISSN: | 1931-843X 1540-9996 |
| DOI: | 10.1089/jwh.2015.5657 |
| Popis: | The majority of women with endometrial cancer (EC) present at an early stage with an associated 5-year survival rate of90%. High rates of early detection are attributed to warning symptoms; however, the prevalence of such symptoms has not been well defined.A case-control study was conducted assessing the prevalence of symptoms in EC patients at a large cancer center compared with healthy controls. Controls included patients seen for an annual gynecologic care visit (AV) or for a gynecological problem-based visit (PV). A self-administered questionnaire was given to all participants addressing EC-associated symptoms, at the time of initial clinic visit. Odds ratios (ORs) were used to compare prevalence of symptoms between EC cases and controls. Logistic regression was used to determine the impact of menopausal status and obesity on symptom prevalence.The cases (n = 75) were significantly older than the AV (n = 203) and PV (n = 151) controls (59.7 vs. 49.8 vs. 51.0 years, p 0.01), had a higher body mass index (35.5 vs. 29.4 vs. 30.9 kg/mSymptoms of both postmenopausal bleeding and abnormal vaginal discharge were significantly higher in EC compared with controls. The presence of such symptoms should raise concern for malignant disease and prompt immediate gynecological evaluation. |
| Databáze: | OpenAIRE |
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