The extracellular matrix modulates the metastatic journey
| Autor: | Valerie M. Weaver, Allison P. Drain, FuiBoon Kai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
dormancy
Cell migration Medical and Health Sciences Metastasis Extracellular matrix angiogenesis 0302 clinical medicine Neoplasms Neoplasm Metastasis tissue tension Cancer 0303 health sciences Neovascularization Pathologic Biological Sciences invasion Extracellular Matrix medicine.anatomical_structure outgrowth pre-metastatic niche integrin extracellular matrix Biology General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences medicine metastasis Animals Humans Neoplasm Invasiveness Fibroblast Molecular Biology Neovascularization 030304 developmental biology mechanotransduction Pathologic Disseminated Tumor Cell intravasation Intravasation Cell Biology Fibroblasts medicine.disease Cancer cell Cancer research 030217 neurology & neurosurgery extravasation mechanics Developmental Biology |
| Zdroj: | Dev Cell Developmental cell, vol 49, iss 3 |
| Popis: | The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth, survival, and invasion of the cancer and modifies fibroblast and immune cell behavior to drive metastasis and impair treatment. Here, we discuss how the tumor matrix regulates metastasis by fostering tumor cell invasion into the stromaand migration toward the vasculature. We describe the role of the tumor matrix in cancer cell intravasation and vascular dissemination. We examine the impact of the matrix on disseminated tumor cell extravasation and on tumor dormancy and metastatic outgrowth. Finally, we discuss the clinical outcome of therapeutics that normalize tumor-matrix interactions. |
| Databáze: | OpenAIRE |
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