Interleukin-6 receptor expression in the peripheral B cells of patients with multicentric Castleman's disease
| Autor: | T. Kakimoto, S Nakamura, Akimoto Y, Nobuyoshi Tsuruoka, M. Koike, Taijiro Ishiyama |
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| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Lymphocyte Activation Immunoglobulin G Pathogenesis Cell surface receptor Antigens CD Internal medicine Medicine Humans Interleukin 6 Receptor B-Lymphocytes Hematology biology business.industry Castleman Disease General Medicine Receptors Interleukin Middle Aged Flow Cytometry Receptors Interleukin-6 Cytokine Interleukin-6 receptor Immunology Antibody Formation biology.protein Female business |
| Zdroj: | Annals of hematology. 73(4) |
| ISSN: | 0939-5555 |
| Popis: | Interleukin-6 (IL-6) is an important regulator of terminal B-cell differentiation. Inappropriate oversynthesis of IL-6 may play primary role in the pathogenesis of multicentric Castleman's disease (MCD). We investigated the expression of the IL-6 receptor (IL-6R) in peripheral B cells from three patients with MCD, as well as the responsiveness of these cells to IL-6. Flow-cytometric analysis showed that IL-6R was significantly expressed on the peripheral B cells of two of three patients. The B cells expressing IL-6R spontaneously produced increased levels of immunoglobulin G (IgG). IL-6R-expressing B cells from one patient showed hyper-responsiveness to IL-6. |
| Databáze: | OpenAIRE |
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