In vitro evaluation of new functional properties of poly-γ-glutamic acid produced by Bacillus subtilis D7
| Autor: | Sang-Mee Lee, Na-Ri Lee, Seong-Yun Jeong, Hong-Joo Son, Geuntae Park, Tae-Hun Go, Chang-Oh Hong |
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| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
Moisturizing effect biology Poly-γ-glutamic acid Agricultural and Biological Sciences(all) Pathogenic bacteria Glutamic acid Bacillus subtilis Antimicrobial activity medicine.disease medicine.disease_cause biology.organism_classification Microbiology Enzyme Listeria monocytogenes chemistry Staphylococcus aureus ACE inhibition activity medicine Original Article Food science Klebsiella pneumonia General Agricultural and Biological Sciences IC50 |
| Zdroj: | Saudi Journal of Biological Sciences. 21(2):153-158 |
| ISSN: | 1319-562X |
| DOI: | 10.1016/j.sjbs.2013.09.004 |
| Popis: | We investigated the functionality of poly-γ-glutamic acid (γ-PGA), which is produced by Bacillus subtilis D7, for its potential applications in medicine and cosmetics. The γ-PGA had angiotensin-converting enzyme (ACE) inhibition activity. ACE inhibition activity was dependent on the γ-PGA concentration; the highest ACE inhibition activity was observed at 1.25mg/l of γ-PGA. IC50 (0.108mg/ml) of the γ-PGA was lower than that of standard ACE inhibitory drug, N-[(S)-mercapto-2-methylpropionyl]-L-proline (0.247mg/ml). The γ-PGA also had water-holding capacity and hygroscopicity. Furthermore, the γ-PGA inhibited growth of some pathogenic bacteria, including Listeria monocytogenes, Salmonella typhimurium, Staphylococcus aureus, Klebsiella pneumonia and Esherichia coli. The γ-PGA exhibited a good metal adsorption capacity; Cr (VI) adsorption capacity of γ-PGA increased with decreasing pH, and the maximal adsorption was observed at pH 2. Our results suggest that γ-PGA may be expected to be widely applied in cosmetics, biomedical and environmental industries with the feature of being less harmful to humans and the environment. |
| Databáze: | OpenAIRE |
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