Animal models of invasive mycoses
Autor: | Henrik Jeldtoft Jensen |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Microbiology (medical) Antifungal Antifungal Agents Disease entity medicine.drug_class Research areas General Medicine Biology Bioinformatics Pathology and Forensic Medicine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Mycoses Invasive Mycoses 030220 oncology & carcinogenesis Models Animal Time course medicine Animals Immunology and Allergy Animal species Invasive Fungal Infections |
Zdroj: | APMIS. 130:427-435 |
ISSN: | 1600-0463 0903-4641 |
Popis: | Animal models of invasive fungal infections have been developed and are applied in a huge number of different animal species for a number of research purposes, for example, the study of pathogenesis, defense mechanisms, and therapeutic strategies. From the different models, which in most cases are based on the same fungal species and often the same strain, as in spontaneous human infections, fundamental results and knowledge of the diagnosis, progression, prophylaxis, and therapy have been achieved. However, in all models, one should be critical with respect to mimicking the disease entity of humans, which is often the focus of the research. In many of the models for instance, the time course is different to the one of humans, and in others, the propensity for localization and containment in specific organs does not parallel the situation in humans. Nevertheless, many animal models of invasive mycoses have proven valuable in a number of research areas. With regard to new generations of anti-mycotic drugs, the models play an essential role in demonstrating antifungal activity, as well as in demonstrating the absence of toxic side effects, a critical step which cannot be accomplished by in vitro studies. |
Databáze: | OpenAIRE |
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