Th2 responses predominate during the early phases of infection in patients with localized cutaneous leishmaniasis and precede the development of Th1 responses
| Autor: | Pascalis, Hervé, Bourreau, Eliane, Gardon, Jacques, Pradinaud, Roger, Pascal, Hervé, Prévot-Linguet, Ghislaine, Kariminia, Amina, Pascal, Launois |
|---|---|
| Přispěvatelé: | Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Institut de Recherche pour le Développement (IRD), Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française] |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty Th2 response Biopsy [SDV]Life Sciences [q-bio] 030231 tropical medicine Immunology Leishmania guyanensis Leishmaniasis Cutaneous Biology Microbiology 03 medical and health sciences 0302 clinical medicine Th2 Cells Cutaneous leishmaniasis Gamma interferon medicine Animals Humans In patient 030304 developmental biology Skin Leishmania 0303 health sciences medicine.diagnostic_test Th1 Cells medicine.disease biology.organism_classification Infectious Diseases [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Cytokines [SDV.IMM]Life Sciences [q-bio]/Immunology Parasitology Th1 response Fungal and Parasitic Infections [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Infection and Immunity Infection and Immunity, American Society for Microbiology, 2003, 71 (4), pp.2244-6. ⟨10.1128/IAI.71.4.2244-2246.2003⟩ |
| ISSN: | 0019-9567 1098-5522 |
| Popis: | Intralesional Th2 responses preceded the development of Th1 responses in localized cutaneous leishmaniasis due to Leishmania guyanensis . Although the number of parasites increased in Th2 lesions, no correlation was found between the levels of cytokine expression and the number of parasites. In contrast, the decreased number of parasites in Th1 lesions is negatively correlated to gamma interferon expression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|