Swallowing disorder and inhibition of cough reflex induced by atropine sulfate in conscious dogs
| Autor: | Terumasa Mino, Takaki Seki, Yasunori Katsura, Tadashi Tsubouchi, Shinichi Sugimoto, Shinji Tsujimoto |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Atropine
Male Baclofen Cough reflex Aspiration pneumonia Pneumonia Aspiration chemistry.chemical_compound Dogs stomatognathic system Swallowing Reflex otorhinolaryngologic diseases medicine Animals Esophagus Pharmacology business.industry lcsh:RM1-950 digestive oral and skin physiology Pharynx Parasympatholytics medicine.disease lcsh:Therapeutics. Pharmacology medicine.anatomical_structure chemistry Cough Anesthesia Molecular Medicine Female business Deglutition Disorders medicine.drug |
| Zdroj: | Journal of Pharmacological Sciences, Vol 106, Iss 3, Pp 452-459 (2008) |
| ISSN: | 1347-8613 |
| Popis: | In this study, the effects of atropine sulfate (atropine) on swallowing and cough reflex were evaluated in the two experimental models in conscious dogs. To evaluate the effects of atropine on swallowing, 1 mL of marker (contrast medium) was injected into the pharynx under X-ray exposure to induce swallowing. Baclofen, used as a positive control, caused marker congestion in the upper esophagus. In our experimental model, atropine (0.02 and 0.1 mg /kg, i.v.) dose-dependently increased not only the number of marker congestions but also that of the swallows. In addition, atropine significantly shortened the onset of first swallowing. In the evaluation of atropine effects on electrically evoked cough reflex induced by two electrodes implanted into the trachea, atropine strongly inhibited the number of coughs at 0.01 or 0.05 mg/kg accompanied with 0.01 or 0.05 mg/kg per hour (i.v.), respectively. These findings indicate that atropine has the potential of causing aspiration pneumonia through induction of swallowing disorder and inhibition of the cough reflex. Keywords:: swallowing disorder, inhibition of cough reflex, anti-cholinergic agent, dog, aspiration pneumonia |
| Databáze: | OpenAIRE |
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